Results 231 to 240 of about 17,469 (269)

Butyrylcholinesterase deficiency

Annales de biologie clinique, 2016
Butyrylcholinesterase (EC 3.1.1.8; BChE) is a sister enzyme of acetylcholinesterase. Though BChE lacks obvious physiological functions, it is of toxicological and pharmacological importance in detoxifying or catabolising ester-containing drugs. Furthermore, individuals deficient in BChE appear asymptomatic, apart from a heightened sensitivity to the ...
Hervé, Delacour, Emmanuel, Dedome, Sébastien, Courcelle, Blandine, Hary, Franck, Ceppa   +4 more
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The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency

The Journal of Pharmacology and Experimental Therapeutics, 2008
Butyrylcholinesterase (BChE) is an important enzyme for metabolism of ester drugs. Many humans have partial or complete BChE deficiency due to genetic variation. Our goal was to create a mouse model of BChE deficiency to allow testing of drug toxicity.
Bin, Li, Ellen G, Duysen, Michaela, Carlson, Oksana, Lockridge   +3 more
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A mechanistic model for butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
A plausible mechanism of action of horse serum butyrylcholinesterase is proposed. It includes substrate activation at the level of deacylation. The rate constant for the acylation of the enzyme appears to be much greater than the rate constant for the deacylation, at low substate concentrations.
H, Eriksson, K B, Augustinsson
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Butyrylcholinesterase formulated in liposomes

Biotechnology and Applied Biochemistry, 1999
Exogenous cholinesterases have the potential to take part in defence against organophosphate toxins, by acting as scavenger systems. Postulating that formulation in liposomes could enhance the toxin‐scavenging potential of these enzymes, we have initiated studies of such formulations and are reporting here our first steps, exploring ...
I, Schumacher, A, Arad, R, Margalit
openaire   +2 more sources

Butyrylcholinesterase in metabolic syndrome

Medical Hypotheses, 2010
Butyrylcholinesterase may have a role in a number of metabolic functions and could affect the expression of insulin resistance syndrome. We present our integrated work using clinical, biochemical and bioinformatic approaches to delineate the possible function of this enzyme.
Gumpeny R, Sridhar, Allam Appa, Rao, Kudipudi, Srinivas, Gumpeny, Nirmala, Gumpeny, Lakshmi, Dasika, Suryanarayna, Padmanabhuni V Nageswara, Rao, Dowluru G S V G L, Kaladhar, Sali Veeresh, Kumar, Tatavarthi Uma, Devi, Turaga, Nitesh, Thota, Hanuman   +11 more
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‘Inverse’ substrates for butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1980
1. 'Inverse'-type substrates for butyrylcholinesterase (acylcholine acylhydrolase, EC 3.1.1.8), i.e., p- and o-nitrophenyl esters of (3-carboxypropyl)-trimethylammonium iodide, (4-carboxybutyl)trimethylammonium iodide and (5-carboxypentyl)trimethylammonium iodide were prepared, and their kinetic parameters for butyrylcholinesterase-catalyzed hydrolysis
M, Nozawa, K, Tanizawa, Y, Kanaoka
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Imaging Butyrylcholinesterase in Multiple Sclerosis

Molecular Imaging and Biology, 2020
Molecular imaging agents targeting butyrylcholinesterase (BChE) have shown promise in other neurodegenerative disorders and may have utility in detecting changes to normal appearing white matter in multiple sclerosis (MS). BChE activity is present in white matter and localizes to activated microglia associated with MS lesions. The purpose of this study
M. W. D. Thorne, M. K. Cash, G. A. Reid, D. E. Burley, D. Luke, I. R. Pottie, S. Darvesh   +6 more
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Butyrylcholinesterase as a Blood Biomarker in Neuroblastoma

Journal of Pediatric Hematology/Oncology, 2017
Blood-based biomarkers are important in the detection of the disease and in the assessment of responses to therapy. In this study, butyrylcholinesterase was evaluated as a potential biomarker in newly diagnosed neuroblastoma (NB) patients at diagnosis and longitudinally during treatment.
Don W, Coulter, Angela D, Boettner, Zbigniew P, Kortylewicz, Stephen P, Enke, Jake A, Luther, Vivek, Verma, Janina, Baranowska-Kortylewicz   +6 more
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Butyrylcholinesterase activity in schizophrenic patients

Annales de biologie clinique, 2011
Butyrylcholinesterase (BChE) is an enzyme that has been investigated for its putative role in neurodegenerative and neuropsychiatric disorders. The aim of our work was to study BChE activity variations in schizophrenic patients and to investigate the involvement of this enzyme in schizophrenia and the importance of determining its activity in this ...
Hajer, Mabrouk, Haithem, Mechria, Anouar, Mechri, Houda, Rahali, Wahiba, Douki, Lotfi, Gaha, Mohamed, Fadhel Najjar   +6 more
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Monoclonal antibodies to mouse butyrylcholinesterase

Chemico-Biological Interactions, 2013
Our immunization strategy introduced recombinant mouse butyrylcholinesterase (BChE) to naïve BChE knockout mice. An extraordinarily strong immune reaction gave rise to a whole spectrum of antibodies with different properties. Two selective and highly efficient monoclonal anti-mouse BChE antibodies 4H1 (IgG1) and 4 C9 (IgG2a), with Kd values in the ...
Katarina, Mrvova, Lucia, Obzerova, Emmanuelle, Girard, Eric, Krejci, Anna, Hrabovska   +4 more
openaire   +2 more sources