Results 231 to 240 of about 24,444 (255)

‘Inverse’ substrates for butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1980
1. 'Inverse'-type substrates for butyrylcholinesterase (acylcholine acylhydrolase, EC 3.1.1.8), i.e., p- and o-nitrophenyl esters of (3-carboxypropyl)-trimethylammonium iodide, (4-carboxybutyl)trimethylammonium iodide and (5-carboxypentyl)trimethylammonium iodide were prepared, and their kinetic parameters for butyrylcholinesterase-catalyzed hydrolysis
M, Nozawa, K, Tanizawa, Y, Kanaoka
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Resveratrol Derived Butyrylcholinesterase Inhibitors

Archiv der Pharmazie, 2013
Novel polyhydroxylated (E)‐stilbenes were synthesized by Mizoroki–Heck reactions and tested for their ability to inhibit the enzymes acetyl‐ and butyrylcholinesterase. Several of them are good inhibitors of butyrylcholinesterase; one of them carrying an extra fluorine substituent is a 94‐fold stronger inhibitor of butyrylcholinesterase than of ...
René, Csuk, Sabrina, Albert, Ralph, Kluge, Dieter, Ströhl   +3 more
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Imaging Butyrylcholinesterase in Multiple Sclerosis

Molecular Imaging and Biology, 2020
Molecular imaging agents targeting butyrylcholinesterase (BChE) have shown promise in other neurodegenerative disorders and may have utility in detecting changes to normal appearing white matter in multiple sclerosis (MS). BChE activity is present in white matter and localizes to activated microglia associated with MS lesions. The purpose of this study
M. W. D. Thorne, M. K. Cash, G. A. Reid, D. E. Burley, D. Luke, I. R. Pottie, S. Darvesh   +6 more
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A mechanistic model for butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
A plausible mechanism of action of horse serum butyrylcholinesterase is proposed. It includes substrate activation at the level of deacylation. The rate constant for the acylation of the enzyme appears to be much greater than the rate constant for the deacylation, at low substate concentrations.
H, Eriksson, K B, Augustinsson
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The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency

The Journal of Pharmacology and Experimental Therapeutics, 2008
Butyrylcholinesterase (BChE) is an important enzyme for metabolism of ester drugs. Many humans have partial or complete BChE deficiency due to genetic variation. Our goal was to create a mouse model of BChE deficiency to allow testing of drug toxicity.
Bin, Li, Ellen G, Duysen, Michaela, Carlson, Oksana, Lockridge   +3 more
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Butyrylcholinesterase (Pseudocholinesterase) Deficiency

2023
Abstract Pseudocholinesterase is a plasma enzyme that functions to hydrolyze esters in succinylcholine, mivacurium, and ester-type local anesthetic. Pseudocholinesterase is produced in the liver and exists as an α2-globulin. Pseudocholinesterase deficiency is a rare disorder that can be acquired or inherited.
Brian Harris, Kris Ferguson
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Butyrylcholinesterase activity in schizophrenic patients

Annales de biologie clinique, 2011
Butyrylcholinesterase (BChE) is an enzyme that has been investigated for its putative role in neurodegenerative and neuropsychiatric disorders. The aim of our work was to study BChE activity variations in schizophrenic patients and to investigate the involvement of this enzyme in schizophrenia and the importance of determining its activity in this ...
Hajer, Mabrouk, Haithem, Mechria, Anouar, Mechri, Houda, Rahali, Wahiba, Douki, Lotfi, Gaha, Mohamed, Fadhel Najjar   +6 more
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Monoclonal antibodies to mouse butyrylcholinesterase

Chemico-Biological Interactions, 2013
Our immunization strategy introduced recombinant mouse butyrylcholinesterase (BChE) to naïve BChE knockout mice. An extraordinarily strong immune reaction gave rise to a whole spectrum of antibodies with different properties. Two selective and highly efficient monoclonal anti-mouse BChE antibodies 4H1 (IgG1) and 4 C9 (IgG2a), with Kd values in the ...
Katarina, Mrvova, Lucia, Obzerova, Emmanuelle, Girard, Eric, Krejci, Anna, Hrabovska   +4 more
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Butyrylcholinesterase inhibitory guaianolides fromAmberboa ramosa

Archives of Pharmacal Research, 2005
Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as 8alpha-hydroxy-11beta-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11alphaH-guai-10(14), 4(15)-dien-6, 12-olide(1), 3beta, 8alpha-dihydroxy-11alpha-methyl-1alphaH, 5alphaH, 6betaH, 7alphaH, 11betaH-guai-10(14 ...
Sher Bahadar, Khan, , Azhar-ul-Haq, Shagufta, Perveen, Nighat, Afza, Abdul, Malik, Sarfraz Ahmad, Nawaz, Muhammad Raza, Shah, Muhammad Iqbal, Choudhary   +7 more
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Ionisation of horse serum butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1970
Abstract The effect of pH on horse serum cholinesterase (acylcholine acyl-hydrolase, EC 3.1.1.8) catalyzed o- nitrophenyl butyrate hydrolysis shows a non-competitive type of inhibition. The K m value is independent of the pH of the medium, and may be regarded as the true dissociation constant of the ES complex. Its value varies only
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