Results 231 to 240 of about 18,202 (269)

Monoclonal antibodies to mouse butyrylcholinesterase

Chemico-Biological Interactions, 2013
Our immunization strategy introduced recombinant mouse butyrylcholinesterase (BChE) to naïve BChE knockout mice. An extraordinarily strong immune reaction gave rise to a whole spectrum of antibodies with different properties. Two selective and highly efficient monoclonal anti-mouse BChE antibodies 4H1 (IgG1) and 4 C9 (IgG2a), with Kd values in the ...
Lucia Obzerova, Emmanuelle Girard, Eric Krejci, Katarina Mrvova, Anna Hrabovska   +4 more
openaire   +3 more sources

Butyrylcholinesterase activity in schizophrenic patients

Annales de biologie clinique, 2011
Butyrylcholinesterase (BChE) is an enzyme that has been investigated for its putative role in neurodegenerative and neuropsychiatric disorders. The aim of our work was to study BChE activity variations in schizophrenic patients and to investigate the involvement of this enzyme in schizophrenia and the importance of determining its activity in this ...
Hajer Mabrouk, Wahiba Douki, Anouar Mechri, Haithem Mechria, Houda Rahali, Lotfi Gaha, Mohamed Fadhel Najjar   +6 more
openaire   +3 more sources

Thermal inactivation of butyrylcholinesterase and acetylcholinesterase

Journal of Protein Chemistry, 1993
Differences were observed in the extent of thermal inactivation of human butyrylcholinesterase (BuChE) and eel acetylcholinesterase (AChE). BuChE was more resistant to 57 degrees C inactivation than was AChE. Thermal inactivation of BuChE was reversible and followed first-order kinetics.
Sharon L. Oxendine, Sybil K. Burgess
openaire   +3 more sources

Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease.

Chemical Communications, 2019
We have identified tryptophan-based selective nanomolar butyrylcholinesterase (BChE) inhibitors. They are defined according to their chemical modularity, novel binding mode revealed by five solved crystal structures with human BChE, low cytotoxicity, and
A. Meden, D. Knez, M. Jukič, X. Brazzolotto, Marija Gršič, A. Pišlar, Abida Zahirović, J. Kos, F. Nachon, J. Svete, S. Gobec, Uroš Grošelj   +11 more
semanticscholar   +1 more source

Production of the Butyrylcholinesterase Knockout Mouse

Journal of Molecular Neuroscience, 2006
The butyrylcholinesterase (BChE [EC 3.1.1.8]) knockout mouse is a model for BChE deficiency in humans. The existence of genetic variants of human BChE was discovered after a new muscle relaxant, succinylcholine, was introduced into the practice of medicine in the late 1950s.
Ellen G. Duysen, Blin Li, Oksana Lockridge, Thomas L. Saunders   +3 more
openaire   +3 more sources

Acetylcholinesterase and Butyrylcholinesterase of Cat

1998
Domestic cat (Felis domesticus) pituitary cDNA and leukocyte genomic DNA were amplified by PCR and sequenced for the protein coding regions of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). ~2 kb of BCHE cDNA and ~4 kb of the ACHE gene with introns were sequenced. Bengal tiger (Panthera tigris) pituitary cDNA was sequenced for BCHE.
Cynthia F. Bartels, Oksana Lockridge, Wei Hua Xie, Amanda K. Miller-Lindholm   +3 more
openaire   +2 more sources

Ionisation of horse serum butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1970
Abstract The effect of pH on horse serum cholinesterase (acylcholine acyl-hydrolase, EC 3.1.1.8) catalyzed o- nitrophenyl butyrate hydrolysis shows a non-competitive type of inhibition. The K m value is independent of the pH of the medium, and may be regarded as the true dissociation constant of the ES complex. Its value varies only
openaire   +3 more sources

Terpenes and Phenylpropanoids as Acetyl- and Butyrylcholinesterase Inhibitors: A Comparative Study.

Current Alzheimer Research, 2019
BACKGROUND Cholinesterase inhibitors are routinely applied in the treatment of Alzheimer's disease and seeking for new cholinesterase inhibitors is a priority. OBJECTIVES Twenty seven compounds were compared, including ones not previously tested.
D. Szwajgier, E. Baranowska-Wójcik
semanticscholar   +1 more source

ChemInform Abstract: Resveratrol Derived Butyrylcholinesterase Inhibitors.

ChemInform, 2013
AbstractSome of the newly synthesized stilbenes of type (III) are good inhibitors for enzymes acetyl‐ and butyrylcholine esterase (ACE and BCE) for instance, (IIIb) is a good inhibitor for ACE whereas, (IIId) is a 94‐fold stronger inhibitor for BCE than for ACE.
Ralph Kluge, Dieter Stroehl, René Csuk, Sabrina Albert   +3 more
openaire   +4 more sources

Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease.

Current Alzheimer Research, 2016
The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine.
S. Darvesh
semanticscholar   +1 more source