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Butyrylcholinesterase in Alzheimer’s Disease
1994Butyrylcholinesterase (BChE, EC.3.1.1.8) is a hydrolytic enzyme of unknown function. Although it is usually considered in conjunction with acetylcholinesterase (AChE), BChE is the product of a different gene, has a much more restricted distribution in the mammalian brain and has no major role in conventional cholinergic neurotransmission.
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Effects of hypophysectomy on acetylcholinesterase and butyrylcholinesterase in the rat
Biochemical Pharmacology, 1983Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities were examined in several tissues of normal and hypophysectomized male and female rats. Significant sex differences in the mean AChE activities of normal rats were observed in the superior cervical ganglion (three times more activity in males) and in serum (50% more activity in ...
Stephen Brimijoin, Joy A. Edwards
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Human Butyrylcholinesterase complexed with N-Propargyliperidines
, 2018The limited clinical efficacy of current symptomatic treatment and minute effect on progression of Alzheimer's disease has shifted the research focus from single targets towards multi-target-directed ligands.
D. Knez +11 more
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Some radiometric microassays for butyrylcholinesterase
Analytical Biochemistry, 1978Abstract A simple method for purifying [ 14 C]butyrylcholine and incubation conditions suitable for estimating butyrylcholinesterase activity are described. Solvent extraction and anion- and cation-exchange procedures for separating butyrylcholine from butyric acid are described and compared.
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Interaction of flavonoids with butyrylcholinesterase [PDF]
The FEBS journal, 2009 Butyrylcholinesterase (BChE ; 3.1.1.8) is a serine hydrolase that belongs to the lipase/protease family with α/β-hydrolase fold. Although its exact physiological function remains unclear, it is known that BChE is responsible for the metabolism of various drugs.
Kovarik, Zrinka +3 more
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Tuning the Stereoselectivity of Butyrylcholinesterase
2003Optically active quinuclidin-3-ol is an important intermediate in the preparation of physiologically or pharmacologically active compounds. Thus, new methods for the efficient production of chiral quinuclidin-3-ols are still examined. It has been shown that stereoselectivity of hydrolyses catalysed by butyrylcholinesterase (BChE ; EC 3.1.1.8) was in ...
Primožič, Ines +2 more
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Serum Butyrylcholinesterase Activity in Leprosy
International Journal of Leprosy and Other Mycobacterial Diseases, 2004Kaurna +5 more
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