Results 231 to 240 of about 3,303,442 (283)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

An analysis of the registration of essential medicines in Namibia: a proxy measure of the availability of essential medicines. [PDF]

J Pharm Policy Pract
Aluvilu AN, Sheehama JEK, Shifotoka SN, Nabyonga-Orem J, Brhlikova P.   +4 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Health Hazards of E-Cigarettes and Heated Tobacco Products: a Comprehensive Analysis of Hazardous Substances and Regulatory Gaps. [PDF]

Nicotine Tob Res
El Bouz M, Neto C, Mansuy T, Becher R, Valen H, Mariussen E, Blanco-Escauriaza DA, González-Marrón A, Zervas E, Havermans A, Talhout R, Staal YCM.   +11 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Safety evaluation of a food enzyme containing leucyl aminopeptidase, oryzin and aspergillopepsin I from the non-genetically modified <i>Aspergillus</i> sp. strain AE-PR. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Lunardi S, Andryszkiewicz M, Cavanna D, Kovalkovicova N, Liu Y.   +17 more
europepmc   +1 more source

Opioids and Cannabis: An Uncertain Combination? [PDF]

Anesthesiology
Boehnke KF.
europepmc   +1 more source

Analysis of 386 alternative medicinal products implicated in liver injury reveal clinically relevant associations with potentially hepatotoxic botanicals, pharmaceutical adulteration, heavy metal contamination, and undisclosed animal content. [PDF]

Front Gastroenterol (Lausanne)
Philips CA, Oommen TT, Theruvath AH, Sreemohan A, Baby A, Ahamed R, Tharakan A, Augustine P.   +7 more
europepmc   +1 more source

Agri-Food By-Products in Dairy Sector a Review Focused on Phytochemicals, Extraction Methods Health Benefits and Applications. [PDF]

Foods
Ratu RN, Stoica F, Balint BA, Veleșcu ID, Crivei IC, Lucaci SP, Lipșa FD, Râpeanu G.   +7 more
europepmc   +1 more source

Significant Variability in Terpene Content and Secondary Organic Aerosol Formation Potential from Ozonolysis of Consumer Product Categories Used Indoors. [PDF]

ACS EST Air
Schwink SK, Schmid MJ, Silberstein JM, Vance ME.   +3 more
europepmc   +1 more source