Results 51 to 60 of about 1,249,876 (248)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Nuclear Pedigree Criteria for the Identification of Individuals Suspected to be at Risk of an Inherited Predisposition to Renal Cancer

Hereditary Cancer in Clinical Practice, 2005
Renal clear cell carcinomas represent about 3% of all visceral cancers and account for approximately 85% of renal cancers in adults. Environmental and genetic factors are involved in the development of renal cancer.
Tołoczko-Grabarek Aleksandra, Sikorski Andrzej, Brzosko Marek, Lubiński Jan   +3 more
doaj   +1 more source

Metastasis to para-aortic lymph nodes cephalad to the renal veins in patients with ovarian cancer

World Journal of Surgical Oncology, 2020
Background In patients with epithelial ovarian cancer, whether metastasis to para-aortic lymph nodes located cephalad to the renal veins (supra-renal PAN) should be classified as regional lymph node metastasis or distant metastasis remains controversial.
Shinichi Komiyama, Masaru Nagashima, Tomoko Taniguchi, Takayuki Rikitake, Mineto Morita   +4 more
doaj   +1 more source

microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion. [PDF]

PLoS ONE, 2012
Metastatic renal cancer manifests multiple signatures of gene expression. Deviation in expression of mature miRNAs has been linked to human cancers.
Nirmalya Dey, Falguni Das, Nandini Ghosh-Choudhury, Chandi Charan Mandal, Dipen J Parekh, Karen Block, Balakuntalam S Kasinath, Hanna E Abboud, Goutam Ghosh Choudhury   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Experiencia en el Manejo del Cáncer Renal Avanzado con Terapia Combinada.

Revista Guatemalteca de Urología, 2020
INTRODUCCIÓN: En el tratamiento del Cáncer Renal en estadios avanzados, la Nefrectomia Radical (NR) hasta hace un poco mas de una década, tomo nuevamente un lugar importante mejorando la sobrevida en los pacientes con la combinación con terapias ...
Estuardo Polanco G., Alfredo Mansilla, Hugo Castro   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

End-stage renal disease and survival in people with diabetes : a national database linkage study [PDF]

, 2014
© The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. Funding This work was supported by the Wellcome Trust through the Scottish Health Informatics Programme (SHIP).
W. Metcalfe, Conway, B., Bell, S, H. C. Looker, D. Levin, Joss, N., Colhoun, H. M., Sattar, N, McKnight, J, N. Joss, Traynor, J. P., Wild, S.; id_orcid, S. Livingstone, Brady, I, J. P. Traynor, Fletcher, E H, Leese, G., Levin, D, Looker, H C, ?, ?, Lindsay, R. S., Pearson, D., Joss, N, Brady, I., Lindsay, R S, Scottish Diabetes Research Network and Scottish Renal Registry, Colhoun, H M, Wild, S, S. Wild, McKnight, J., B. Conway, Livingstone, S., Sattar, N., J. Mcknight, Traynor, J P, Wild, S., N. Halbesma, Pearson, D, Levin, D., N. Sattar, D. Pearson, Leese, G, Halbesma, N, Halbesma, N., Metcalfe, W, Livingstone, S, Looker, H. C., Bell, S., R. S. Lindsay, Philip, S, I. Brady, S. Bell, G. Leese, Bell, S.; id_orcid, Metcalfe, W., Conway, B, Philip, S., S. Philip, E. H. Fletcher, Fletcher, E. H.   +59 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source