Results 1 to 10 of about 35,386 (118)

Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib [PDF]

BMC Medicine
Background Sunitinib is an orally administered novel multi-targeted therapy for treating tumors especially for gastrointestinal stromal tumors and metastatic renal cell carcinoma (RCC) but associated with cardiovascular toxicity.
Shi-yu Huang, Min Hu, Yu-jie Chen, Jia-chen Liu, Zhi-yuan Yao, Zhi-yuan Chen, Xiu-heng Liu, Lei Wang   +7 more
doaj   +2 more sources

PABPC1-induced stabilization of PGK1 mRNA reduces apoptosis and sunitinib sensitivity in renal cell carcinoma by suppressing endoplasmic reticulum stress [PDF]

Cell Death and Disease
Sunitinib resistance poses a significant challenge in the management of advanced and metastatic clear cell renal cell carcinoma (ccRCC). Although RNA-binding proteins (RBPs) have recently emerged as important regulators of tumorigenesis, their roles in ...
Xinran Chen, Senming Cao, Tongyu Jia, Changwei Shi, Zhenze Yang, Qiyang Liang, Xu Zhang, Liangyou Gu, Xin Ma, Qingbo Huang, Xiubin Li   +10 more
doaj   +2 more sources

Efficacy and safety analysis of TACE + sunitinib vs. sunitinib in the treatment of unresectable advanced renal cell carcinoma: a retrospective study

BMC Cancer, 2023
Background Since renal cell carcinoma(RCC) is insensitive to conventional chemoradiotherapy, molecularly targeted drugs are commonly used treatments for unresectable advanced RCC.
Haohao Lu, Qing Ye, Chuansheng Zheng, Li Fan, Xiangwen Xia   +4 more
doaj   +1 more source

Sunitinib induced hepatotoxicity in L02 cells via ROS-MAPKs signaling pathway

Frontiers in Pharmacology, 2022
Sunitinib is a multi-targeted tyrosine kinase inhibitor with remarkable anticancer activity, while hepatotoxicity is a potentially fatal adverse effect of its administration.
Ting-Li Tang, Yan Yang, Lin Guo, Shuang Xia, Bikui Zhang, Miao Yan   +5 more
doaj   +1 more source

N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma

Molecular Cancer, 2022
Background Sunitinib resistance can be classified into primary and secondary resistance. While accumulating research has indicated several underlying factors contributing to sunitinib resistance, the precise mechanisms in renal cell carcinoma are still ...
Yuanlei Chen, Zeyi Lu, Chao Qi, Chenhao Yu, Yang Li, Wang Huan, Ruyue Wang, Wenqin Luo, Danyang Shen, Lifeng Ding, Liangliang Ren, Haiyun Xie, Dingwei Xue, Mingchao Wang, Kangxin Ni, Liqun Xia, Jun Qian, Gonghui Li   +17 more
doaj   +1 more source

Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway

BMC Pharmacology and Toxicology, 2021
Background Sunitinib is known to cause cardiotoxicity in clinical settings. However, among sunitinib-treated patients experiencing adverse cardiac events, decreased cardiac function was reportedly reversible in > 50% of the patients. We previously showed
Toshikatsu Matsui, Tadahiro Shinozawa
doaj   +1 more source

Sunitinib treatment promotes metastasis of drug-resistant renal cell carcinoma via TFE3 signaling pathway

Cell Death and Disease, 2021
Receptor tyrosine kinase (RTK) inhibitors, such as sunitinib and sorafenib, remain the first-line drugs for the treatment of mRCC. Acquired drug resistance and metastasis are the main causes of treatment failure.
Luchao Li, Shuo Zhao, Zhengfang Liu, Nianzhao Zhang, Shuo Pang, Jikai Liu, Cheng Liu, Yidong Fan   +7 more
doaj   +1 more source

Role of Sam68 in Sunitinib induced renal cell carcinoma apoptosis

Cancer Medicine, 2022
Sunitinib is one of the first‐line targeted drugs for metastatic renal cell carcinoma (RCC) with dual effects of antiangiogensis and proapoptosis. Sam68 (Src‐associated in mitosis, 68 KDa), is found being involved in cell apoptosis.
Zeshen Wu, Yulu Peng, Longbin Xiong, Jun Wang, Zhen Li, Kang Ning, Minhua Deng, Ning Wang, Wensu Wei, Zhiyong Li, Pei Dong, Chunping Yu, Fangjian Zhou, Zhiling Zhang   +13 more
doaj   +1 more source

Insulin Resistance and Pellino-1 Mediated Decrease in the Activities of Vasodilator Signaling Contributes to Sunitinib-Induced Hypertension

Frontiers in Pharmacology, 2021
Antiangiogenic tyrosine kinases inhibitors induce hypertension, which may increase the incidents of cardiovascular complications and limit their use. However, the mechanisms by which usage of TKIs results in hypertension have not been fully understood ...
Yang Liu, Liang-Liang Tang, Chen Liang, Ming-Ming Wu, Zhi-Ren Zhang, Zhi-Ren Zhang   +5 more
doaj   +1 more source

LncRNA HOTAIR induces sunitinib resistance in renal cancer by acting as a competing endogenous RNA to regulate autophagy of renal cells

Cancer Cell International, 2020
Background Cell autophagy has been proposed to be involved in drug resistance therapy. However, how the long non-coding RNA (lncRNA) reduces risks of drug resistance in renal cancer (RC) cells needs a thorough inquiry.
Dechao Li, Changfu Li, Yongsheng Chen, Lichen Teng, Yan Cao, Wentao Wang, Hongxin Pan, Yongpeng Xu, Dan Yang   +8 more
doaj   +1 more source