Results 101 to 110 of about 7,255 (192)

Understanding aspects of alginate biosynthesis and regulation by Pseudomonas aeruginosa : a thesis presented in partial fulfilment of the requirements of the degree of Doctor of Philosophy in Microbiology at Massey University, Palmerston North, New Zealand [PDF]

, 2017
Alginate is a medically and industrially important polymer produced by seaweeds and certain bacteria. The bacterium Pseudomonas aeruginosa over-produces alginate during cystic fibrosis lung infections, forming biofilms, making the infection difficult to ...
Wang, Yajie
core  

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

c-di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motility

eLife, 2013
Individual cell heterogeneity is commonly observed within populations, although its molecular basis is largely unknown. Previously, using FRET-based microscopy, we observed heterogeneity in cellular c-di-GMP levels.
Bridget R Kulasekara, Cassandra Kamischke, Hemantha D Kulasekara, Matthias Christen, Paul A Wiggins, Samuel I Miller   +5 more
doaj   +1 more source

c-di-AMP: An essential molecule in the signaling pathways that regulate the viability and virulence of gram-positive bacteria [PDF]

, 2017
Signal transduction pathways enable organisms to monitor their external environment and adjust gene regulation to appropriately modify their cellular processes.
Cho, Kyu Hong, Fahmi, Tazin, Port, Gary C   +2 more
core   +2 more sources

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

The Diguanylate Cyclase HsbD Intersects with the HptB Regulatory Cascade to Control Pseudomonas aeruginosa Biofilm and Motility.

PLoS Genetics, 2016
The molecular basis of second messenger signaling relies on an array of proteins that synthesize, degrade or bind the molecule to produce coherent functional outputs.
Martina Valentini, Benoît-Joseph Laventie, Joana Moscoso, Urs Jenal, Alain Filloux   +4 more
doaj   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c‐di‐GMP effector BerB

MicrobiologyOpen, 2017
Knowledge about the molecular mechanisms that are involved in the regulation of biofilm formation is essential for the development of biofilm‐control measures.
Mustafa Fazli, Morten Rybtke, Elisabeth Steiner, Elisabeth Weidel, Jens Berthelsen, Julie Groizeleau, Wu Bin, Boo Zhao Zhi, Zhang Yaming, Volkhard Kaever, Michael Givskov, Rolf W. Hartmann, Leo Eberl, Tim Tolker‐Nielsen   +13 more
doaj   +1 more source

Investigation of the biosynthesis of exopolysaccharides within the biofilm matrix of Pseudomonas aeruginosa and Pseudomonas syringae pv. actinidiea : a thesis presented in partial fulfilment of the requirements for degree of Doctor of Philosophy in Microbiology and Genetics at Massey University, Manawatu, New Zealand [PDF]

, 2017
Polysaccharides are highly abundant natural biopolymers, which have biologically significant structural functions in living organisms. Various polysaccharides, with specific physicochemical properties, contribute to biofilm formation; defined as cell ...
Ghods, Shirin
core  

Understanding the errors of SHAPE-directed RNA structure modeling

, 2011
Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms.
Aviran S., Brunel C., Butler E. B., Byrne R. T., Cate J. H., Christopher C. VanLang, Collins K., Correll C. C., Cruz J. A., Darty K., Das R., Das R., Deigan K. E., Efron B., Efron B., Felsenstein J., Gesteland R. F., Hickey D. R., Hofacker I. L., Kladwang W., Kladwang W., Kulshina N., Kwon M., Lemay J. F., Leontis N. B., Levitt M., Mandal M., Mandal M., Mathews D. H., Mathews D. H., Mills D. R., Mitra S., Mortimer S. A., Noller H. F., Pablo Cordero, Panning B., Pedersen J. S., Regulski E. E., Rhiju Das, Russell R., Russell R., Serganov A., Smith K. D., Staley J. P., Sudarsan N., Sussman J. L., Takamoto K., Vasa S. M., Watts J. M., Wilkinson K. A., Wilkinson K. A., Winkler W. C., Wipapat Kladwang, Yoon S.   +53 more
core   +1 more source