Results 41 to 50 of about 26,559,672 (198)
Synthesis of the Isodityrosine Moiety of Seongsanamide A–D and Its Derivatives
Marine Drugs, 2023 The concise and highly convergent synthesis of the isodityrosine unit of seongsanamide A–D and its derivatives bearing a diaryl ether moiety is described.
Yang Xie +7 more
doaj +1 more source
Ligand-Enabled, Palladium-Catalyzed Beta-C (sp3)–H Arylation of Weinreb Amides [PDF]
, 2018 We report the development of Pd(II)-catalyzed C(sp3)–H arylation of Weinreb amides. A pyridinesulfonic acid ligand is designed to accommodate the weak, neutral coordinating property of Weinreb amides via preserving the cationic character of Pd center ...
Nikita, Chekshin +3 more
core +2 more sources
Angewandte Chemie, EarlyView.Here we report two nonalternant polycyclic aromatic hydrocarbons (PAH) (1 and 2), which contain two and four consecutive pentagons, respectively. Under acidic conditions, 1 and 2 dimerize to afford the axially chiral dimers AC1 and AC2. The central azulene moiety in both 2 and AC2 shows an unusually short transannular bond of 1.366 Å.
Chang Wang +3 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2015 We report herein a two or three step synthesis of fluorinated π-conjugated oligomers through iterative C–H bond arylations. Palladium-catalyzed desulfitative arylation of heteroarenes allowed in a first step the synthesis of fluoroaryl-heteroarene units ...
Fatiha Abdelmalek +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.The use of 1,1,3,3‐tetramethyldisiloxane (TMDSO) and potassium tert‐butoxide enables direct alkylation of weakly acidic carbon–hydrogen bonds with alkyl halides. Experimental and computational studies support the formation of a substrate‐associated hydride‐like base, providing a single‐step alternative to the classical deprotonation and electrophile ...
Piers St. Onge +4 more
wiley +2 more sources
Ligand-Enabled Pd(II)-Catalyzed Enantioselective β-C(sp3)-H Arylation of Aliphatic Tertiary Amides [PDF]
, 2022 Amide is one of the most widespread functional groups in organic and bioorganic chemistry, and it would be valuable to achieve stereoselective C(sp3)-H functionalization in amide molecules. Pd(II) catalysis has been prevalently used in the C-H activation
Lei, Jiao +2 more
core +2 more sources
Angewandte Chemie, EarlyView.1,2‐Aryl migration involving in situ‐generated alkyl iodine(III) species proceeds through a previously unrecognized 1,2‐C/I(III) dyotropic rearrangement. Migratory aryl fluorination, acetoxylation, and alkoxylation of 2‐alkyl‐2‐aryl‐3‐iodopropanoates provide α‐heterofunctionalized products, accompanied by aryl migration from the α‐ to the β‐position ...
Chen‐Xu Liu +3 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani +7 more
wiley +2 more sources
Direct arylation catalysis with chloro[8-(dimesitylboryl)quinoline-κN]copper(I)
Beilstein Journal of Organic Chemistry, 2016 We report direct arylation of arylhalides with unactivated sp2 C–H bonds in benzene and naphthalene using a copper(I) catalyst featuring an ambiphilic ligand, (quinolin-8-yl)dimesitylborane.
Sem Raj Tamang, James D. Hoefelmeyer
doaj +1 more source
“On Water” Palladium Catalyzed Direct Arylation of 1H-Indazole and 1H-7-Azaindazole
Molecules, 2020 The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and C3 ...
Khadija Gambouz +7 more
doaj +1 more source