C—H Activation of Unbiased C(sp3)—H Bonds [PDF]
, 2022 The selective functionalization of non-activated C(sp3)—H bonds is a major challenge in chemistry. Here, we have developed an [Au]-catalyzed C(sp3)-H activation of common 1 bromoalkynes into a library of diverse 3D-scaffolds.
Pablo, Barrio +6 more
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Computational exploration of the reaction mechanism of the Cu+-catalysed synthesis of indoles from N-aryl enaminones [PDF]
Royal Society Open Science, 2016 We have studied the role of Cu+-phenantroline as a catalyst in the cyclization of N-aryl-enaminones using density-functional theory computations. The catalyst was found to bind the substrate upon deprotonation of its eneaminone, and to dramatically ...
Carlos E. P. Bernardo, Pedro J. Silva
doaj +1 more source
Reversing the Regioselectivity of Asymmetric C ̶ H and N ̶ H Bond Annulation with Bromoalkynes Under Cobalt(III)-Catalysis [PDF]
, 2023 Metal-catalyzed C-H bond annulation strategy offers a versatile platform, allowing the construction of complex p-chiral molecules through atom- and step-economical fashion. However, regioselective insertion of -coupling partner between M-C bond and high
Subramani , Kumaran +4 more
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Synergistic C-H bond activation across molybdenum-iridium multiply bonded complexes: a cascade of transformations. [PDF]
Chem SciInternational audienceeterobimetallic compounds offer unique opportunities for activating substrates through cooperative interactions between two distinct metal centers, potentially leading to catalytic reactivity beyond the reach of monometallic systems.
Dubrawski Z +5 more
europepmc +2 more sources
Substrate Conformation Masquerades Two different Oxidants in Aromatic C-H and C-F bond activation by Heme-dependent Tyrosine Hydroxylase [PDF]
, 2022 A recently discovered heme-dependent enzyme TyrH offers a green approach for functionalizing the high-strength C-H and C-F bonds in aromatic compounds.
Gary, Black +5 more
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Ni-catalyzed benzylic β-C(sp3)–H bond activation of formamides
Nature Communications, 2022 The development of 3d-metal-catalyzed β-C–H bond activation via 4-membered metallacycles remains an elusive challenge. Here, the authors report a Ni-Al bimetal-catalyzed β-C(sp3)–H bond activation of formamides via 4-membered nickelacycles.
Rong-Hua Wang +7 more
doaj +1 more source
Co(III) Intermediates in Cobalt-Catalyzed, Bidentate Chelation Assisted C(sp2)-H Functionalizations
Inorganics, 2023 The C-H bond activation and functionalization is a powerful tool that provides efficient access to various organic molecules. The cobalt-catalyzed oxidative C-H bond activation and functionalization has earned enormous interest over the past two decades.
Aleksandrs Cizikovs, Liene Grigorjeva
doaj +1 more source
Enantioselective C–P Bond Formation through C(sp3)–H Functionalization [PDF]
, 2023 An unprecedented enantioselective C–P bond formation has been developed through a C(sp3)–H activation in an oxidation step followed by an organocatalyzed hydrophosphonylation protocol. The asymmetric organocatalytic Pudovik reaction has been successfully
Devan , Horn +6 more
core +1 more source
Introducing Ion Mobility Mass Spectrometry to Identify Site-Selective C–H Bond Activation in N-Heterocyclic Carbene Metal Complexes [PDF]
, 2022 The activation of C−H bonds in a selective manner still constitutes a major challenge from a synthetic point of view; thus, it remains an active area of fundamental and applied research. Herein, we introduce ion mobility spectrometry mass spectrometry-
Ibañez-Ibañez, Laura +13 more
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Identical Spin Multi-State Reactivity Towards C-H Bond Activation in High-valent Fe/Mn-Oxo/Hydroxo Species [PDF]
, 2022 Activation of C-H bonds using an earth-abundant metal catalyst is one of the top challenges of chemistry where high-valent Fe/Mn-O/OH biomimic species play an important role. There are several open questions related to the comparative oxidative abilities
Abinash, SWAIN +4 more
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