Results 171 to 180 of about 123,266 (262)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Silver-Catalyzed C(sp3)–H Functionalization

ACS Organic & Inorganic Au
Masoud Sadeghi
doaj   +1 more source

Stable BF₂ Boracycles as Versatile Reagents for Selective Ortho C-H Functionalization. [PDF]

Angew Chem Int Ed Engl
Shinde GH, Babiker J, Mebrahtu M, Prigent A, Foucras G, Aher YN, Noa FMA, Johansson MJ, Košmrlj J, Jansen-van Vuuren RD, Cailly T, Sundén H.   +11 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities

ACS Central Science, 2016
John F. Hartwig, Matthew A. Larsen
doaj   +1 more source

Non-radical pathways control methane sulfonation <i>versus</i> oxygenation C-H functionalization selectivity with Hg(ii) and Au(iii) catalysis. [PDF]

Chem Sci
Koppaka A, Cullimore C, Joy J, Kraus A, Periana RA, Ess DH.   +5 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Palladium-Catalyzed Non-Directed C─H Functionalization of Arenes with Trifluoromethylated Olefins. [PDF]

Chemistry
Stockmann L, Empel C.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Photo-Mediated Silacyclization by Wavelength-Dependent Selective C─F or C─H Functionalization. [PDF]

Angew Chem Int Ed Engl
Wang G, Yuan Y, Wang C, Ren B, Ang HT, Zhou R, Wu J.   +6 more
europepmc   +1 more source