Results 191 to 200 of about 26,610,004 (213)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

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Photoredox-Catalyzed C–H Functionalization Reactions

Chemical Reviews, 2022
David Nicewicz
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Photocatalytic Late-Stage C–H Functionalization

Chemical Reviews, 2023
Peter Bellotti, Huan-Ming Huang, Frank Glorius   +2 more
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Rhodium-Catalyzed Asymmetric C–H Functionalization Reactions

Chemical Reviews, 2023
Shu-Li You, Qing Gu, Chen-Xu Liu
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Electrochemical Late-Stage Functionalization

Chemical Reviews, 2023
Lutz Ackermann, Suman Dana, Nikolaos Kaplaneris   +2 more
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Late-stage Functionalization for Improving Drug-like Molecular Properties

Chemical Reviews, 2023
Jonathan Danon, Andrew Montgomery, Michael Kassiou   +2 more
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Surface Functionalization and Texturing of Optical Metasurfaces for Sensing Applications

Chemical Reviews, 2022
Colin Jackson, Antonio Tricoli, Buddini I Karawdeniya   +2 more
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Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(sp3)–H Bonds

Chemical Reviews, 2021
Bin Liu, Andrew Romine, Bingfeng Shi
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