Results 211 to 220 of about 6,068,014 (260)

Synthesis of Protoberberine Alkaloids by C-H Functionalization and Anionic Aza-6π-Electrocyclization: Dual Activity as AMPK Activators and Inhibitors. [PDF]

JACS Au
Cao Y, Perry JSM, Zhang E, Trinh A, Kacker A, Cruz S, Ceballos H, Pan A, Huang W, Kou KGM.   +9 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Catalyst-controlled directing group translocation in the site selective C-H functionalization of 3-carboxamide indoles and metallocarbenes. [PDF]

Nat Commun
Gu K, Hall MT, Tucker ZD, Durling GM, Ashfeld BL.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones. [PDF]

ACS Synth Biol
Wang R, Nji Wandi B, Schwartz N, Hecht J, Ponomareva L, Paige K, West A, Desanti K, Nguyen J, Niemi J, Thorson JS, Shaaban KA, Metsä-Ketelä M, Nybo SE.   +13 more
europepmc   +1 more source

Metal-Organic Framework-based Efficient Singlet Heterogeneous Photoredox Catalyst for Aerobic C-H Functionalization. [PDF]

ACS Catal
Rajasree SS, Saha B, Kelly GM, Phillips EN, Maindan K, Li A, Slusarczyk T, Deria P.   +7 more
europepmc   +1 more source

Asymmetric C-H Functionalization of <i>N</i>-Boc-2,5-dihydro-1<i>H</i>-pyrrole and Its Application as a Key Step in the Synthesis of (-)-Dragocin D. [PDF]

J Am Chem Soc
Nguyen TH, Shimabukuro K, Musaev DG, Bacsa J, Navarro A, Davies HML.   +5 more
europepmc   +1 more source

Derivatization of 2,1,3-Benzothiadiazole via Regioselective C-H Functionalization and Aryne Reactivity. [PDF]

J Org Chem
Kunz S, Barnå F, Urrutia MP, Ingner FJL, Martínez-Topete A, Orthaber A, Gates PJ, Pilarski LT, Dyrager C.   +8 more
europepmc   +1 more source

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Photocatalytic Late-Stage C–H Functionalization

Chemical Reviews, 2023
The emergence of modern photocatalysis, characterized by mildness and selectivity, has significantly spurred innovative late-stage C-H functionalization approaches that make use of low energy photons as a controllable energy source.
Peter Bellotti, Huan-Ming Huang, Frank Glorius   +2 more
exaly   +2 more sources

Rhodium-Catalyzed Asymmetric C–H Functionalization Reactions

Chemical Reviews, 2023
This review summarizes the advancements in rhodium-catalyzed asymmetric C-H functionalization reactions during the last two decades. Parallel to the rapidly developed palladium catalysis, rhodium catalysis has attracted extensive attention because of its
Shu-Li You, Qing Gu, Chen-Xu Liu
exaly   +2 more sources