Results 61 to 70 of about 206,495 (234)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme [PDF]

, 2017
C–H bonds are ubiquitous structural units of organic molecules. Although these bonds are generally considered to be chemically inert, the recent emergence of methods for C–H functionalization promises to transform the way synthetic chemistry is performed.
A Sharma, Andrew R. Buller, C Liang, CC Farwell, Christopher K. Prier, CJC Whitehouse, CK Prier, DN Zalatan, ET Hennessy, EW Svastits, F Collet, Frances H. Arnold, G-D Roiban, H Li, HM Key, HML Davies, I Bertini, I Nägeli, J Yamaguchi, JA McIntosh, JD Bloom, JF Hartwig, JL Jeffrey, K Godula, LM Podust, M Barniol-Xicota, M Bordeaux, M Ochiai, M Schrewe, M Yamawaki, P Both, P Dydio, P Srivastava, PS Coelho, Q Michaudel, R Singh, RP Reddy, Ruijie K. Zhang, Sabine Brinkmann-Chen, T Ankner, TK Hyster, TK Hyster, TL Poulos, VB Urlacher, X Huang, Y Kohmura, Y Nishioka   +46 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Cobalt(III)-catalyzed asymmetric ring-opening of 7-oxabenzonorbornadienes via indole C–H functionalization

Nature Communications, 2023
Asymmetric ring-opening (ARO) reactions, which can help quickly build molecular complexity, have not been extensively shown via β-oxygen elimination. Here, the authors report a cobalt(III)-catalyzed ARO reaction, providing mechanistic insights and the ...
Yang Zheng, Wen-Yun Zhang, Qing Gu, Chao Zheng, Shu-Li You   +4 more
doaj   +1 more source

Regioselective Access to Sultam Motifs through Cobalt-Catalyzed Annulation of Aryl Sulfonamides and Alkynes using an 8-Aminoquinoline Directing Group [PDF]

, 2015
The use of cobalt as catalyst in direct C[BOND]H activation protocols as a replacement for more expensive second row transition metals is currently attracting significant attention.
Ackermann, Ackermann, Ackermann, Andou, Beletskaya, Bernini, Casitas, Chen, Collins, Corbet, Daugulis, De Santis, Ding, Dong, Gensch, Godula, Grigorjeva, Grigorjeva, Grigorjeva, Guimond, He, Huestis, Hummel, Hyster, Ikemoto, Jia, Jiménez-Hopkins, Kajita, Kaneko, Larock, Lee, Li, Li, Li, Liu, Liu, Lombardino, Lyons, Ma, Majumdar, Merten, Morimoto, Mousseau, Pawar, Pham, Punji, Rakshit, Rassadin, Shah, Shi, Shilov, Shuklov, Song, Song, Stuart, Stuart, Sun, Sun, Suzuki, Tasker, Ueura, Ueura, Umeda, Wells, Wencel-Delord, Wendlandt, Wu, Wu, Wu, Wu, Wu, Yamaguchi, Yeung, Yoshino, Yu, Zhang, Zhang, Zhang, Zhao   +78 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Recent Advances in the Nickel-Catalyzed Alkylation of C-H Bonds

Molecules
Functionalization of C-H bonds has emerged as a powerful strategy for converting inert, nonfunctional C-H bonds into their reactive counterparts.
Franc Požgan, Uroš Grošelj, Jurij Svete, Bogdan Štefane, Hamad H. Al Mamari   +4 more
doaj   +1 more source

Cobalt-catalysed site-selective intra- and intermolecular dehydrogenative amination of unactivated sp3 carbons [PDF]

, 2015
Cobalt-catalysed sp2 C–H bond functionalization has attracted considerable attention in recent years because of the low cost of cobalt complexes and interesting modes of action in the process. In comparison, much less efforts have been devoted to the sp3
Ge, Haibo, Li, Guigen, Sun, Hao, Wu, Xuesong, Yang, Ke, Zhao, Yan   +5 more
core   +1 more source

Exploiting double exchange Diels-Alder cycloadditions for immobilization of peptide nucleic acids on gold nanoparticles [PDF]

, 2020
The generation of PNA-decorated gold nanoparticles (AuNPs) has revealed to be more difficult as compared to the generation of DNA-functionalized ones. The less polar nature of this artificial nucleic acid system and the associated tendency of the neutral
Cadoni, Enrico, Madder, Annemieke, Mancin, Fabrizio, Manicardi, Alex, Rosa-Gastaldo, Daniele   +4 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source