Results 61 to 70 of about 123,266 (262)

Palladium-Catalyzed Directed para C-H Functionalization of Phenols

, 2016
Various practical methods for the selective C-H functionalization of the ortho and recently also of the meta position of an arene have already been developed.
BAG, S, MAITI, D, PATRA, T, PIMPARKAR, S, Pimparkar, Sandeep, MODAK, A, Patra, Tuhin, DEY, A, Kancherla, Rajesh, Dey, Aniruddha, Mondal, Anirban, Agasti, Soumitra, MONDAL, A, Bag, Sukdev, Maiti, Debabrata, KANCHERLA, R, AGASTI, S, Modak, Atanu   +17 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Novel Strategies in C-H Oxidations for Natural Product Diversification—A Remote Functionalization Application Summary

Frontiers in Chemistry, 2021
Selectively activating the distal inactive C-H bond for functionalization is one of the on-going challenge in organic synthetic chemistry. In recent years, benefiting from the development of selective synthesis methods, novel methodologies not only make ...
Huang Junrong, Huang Junrong, Yang Min, Dai Chuan, Zhou Yajun, Fang Huilong, Zhu Lizhi, Zhu Lizhi, Yin Feng, Yin Feng, Li Zigang, Li Zigang   +11 more
doaj   +1 more source

Multitask Prediction of Site Selectivity in Aromatic C-H Functionalization Reactions

, 2019
Aromatic C-H functionalization reactions are an important part of the synthetic chemistry toolbox. Accurate prediction of site selectivity can be crucial for prioritizing target compounds and synthetic routes in both drug discovery and process chemistry.
Klavs F. Jensen (5815258), Jensen, Klavs F, Thomas J., Struble, Connor W. Coley (5815187), Connor W., Coley, Coley, Connor Wilson, Struble, Thomas J, Klavs F., Jensen, Thomas J. Struble (5909216)   +8 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

C–H Functionalization via Iodine-mediated Electrocatalysis and C–N Bond Formation

, 2022
The access of heterocyclic compounds via direct amination of C-H bonds are of vital interest because of their role in pharmaceutical and natural products. The combination of molecular iodine and electricity activates benzylic C-H bond and facilitates the
Guilherme. M., Martins, Nisar, Ahmed
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cobalt(III)-catalyzed asymmetric ring-opening of 7-oxabenzonorbornadienes via indole C–H functionalization

Nature Communications, 2023
Asymmetric ring-opening (ARO) reactions, which can help quickly build molecular complexity, have not been extensively shown via β-oxygen elimination. Here, the authors report a cobalt(III)-catalyzed ARO reaction, providing mechanistic insights and the ...
Yang Zheng, Wen-Yun Zhang, Qing Gu, Chao Zheng, Shu-Li You   +4 more
doaj   +1 more source

Ligand Accelerated Hydrogen Isotope Exchange: Switching C-H Activation from Functionalization Towards C-D Bond Formation

, 2023
Hydrogen isotope exchange (HIE) has emerged as a unique strategy for labelling, affording plenty of deuterated chemicals with varieties in patterns.
Jianfei, Bai, Bencan, Tang, Dawei, Xu, Jiakai, Lu, Zhi-Jiang, Jiang, Zhanghua, Gao, Jia, Chen   +6 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source