Results 61 to 70 of about 26,610,004 (213)

Intramolecular C-H Functionalization of alpha-Alkyl-alpha-diazoesters towards the Synthesis of Lactones [PDF]

Intramolecular C-H functionalization was achieved using rhodium-catalysis with alpha-alkyl-alpha-diazoesters. Dirhodium tetratriphenylacetate (Rh2(TPA)4), a sterically bulky achiral catalyst was found to enable the formation of lactones.
Jeffrey, Mighion, Bijaya, Bagale, Aubree, Nolan, Elizabeth, Heuser   +3 more
core   +1 more source

C–H Functionalization via Iodine-mediated Electrocatalysis and C–N Bond Formation [PDF]

, 2022
The access of heterocyclic compounds via direct amination of C-H bonds are of vital interest because of their role in pharmaceutical and natural products. The combination of molecular iodine and electricity activates benzylic C-H bond and facilitates the
Guilherme. M., Martins, Nisar, Ahmed
core   +1 more source

Coumarins Synthesis and Transformation via C–H Bond Activation—A Review

Inorganics, 2022
For several decades, coumarins have attracted considerable attention due to the fact of their application in diverse fields such as medical science and biomedical research as well as several industrial branches.
Katarzyna Szwaczko
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Cobalt(III)-catalyzed asymmetric ring-opening of 7-oxabenzonorbornadienes via indole C–H functionalization

Nature Communications, 2023
Asymmetric ring-opening (ARO) reactions, which can help quickly build molecular complexity, have not been extensively shown via β-oxygen elimination. Here, the authors report a cobalt(III)-catalyzed ARO reaction, providing mechanistic insights and the ...
Yang Zheng, Wen-Yun Zhang, Qing Gu, Chao Zheng, Shu-Li You   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Imine as a Linchpin Approach for Distal C(sp2)–H Functionalization [PDF]

, 2020
Despite the widespread applications of C–H functionalization, controlling site selectivity remains a significant challenge. Covalently attached directing group (DG) served as an ancillary ligand to ensure proximal ortho-, distal meta- and para-C-H ...
Sadhan, Jana, Suman, Bhowmick, Nupur, Goswami, Sukumar, Pradhan, Soumya, Kumar Sinha, Sukdev, Bag, Debabrata, Maiti   +6 more
core   +2 more sources

Remote C−H functionalization using radical translocating arylating groups

Nature Communications, 2018
Selective remote functionalization of aliphatic C(sp3)−H bonds is highly challenging and often requires transition metals and/or directing groups. Here, the authors show the γ-arylation of aliphatic alcohols via a two-step radical translocation and ...
Florian W. Friese, Christian Mück-Lichtenfeld, Armido Studer   +2 more
doaj   +1 more source

Novel Strategies in C-H Oxidations for Natural Product Diversification—A Remote Functionalization Application Summary

Frontiers in Chemistry, 2021
Selectively activating the distal inactive C-H bond for functionalization is one of the on-going challenge in organic synthetic chemistry. In recent years, benefiting from the development of selective synthesis methods, novel methodologies not only make ...
Huang Junrong, Huang Junrong, Yang Min, Dai Chuan, Zhou Yajun, Fang Huilong, Zhu Lizhi, Zhu Lizhi, Yin Feng, Yin Feng, Li Zigang, Li Zigang   +11 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source