Results 61 to 70 of about 28,198,830 (257)
Use of Emerging C–H Functionalization Methods to Implement Strategies for the Divergent Total Syntheses of Bridged Polycyclic Natural Products [PDF]
, 2023 Carbon–hydrogen (C–H) bonds are ubiquitous in complex natural products. Over the past three decades, many methods to convert C–H bonds distal from functional groups, which were generally considered inert, have been developed.
Richmond, Sarpong, Goh, Sennari
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Steric, Electronic and Conformational Synergistic Effects in the Au(I)-catalyzed alpha-C-H Bond Functionalization of Tertiary Amines [PDF]
, 2022 Direct C-H bond functionalization is a useful strategy for the straightforward formation of C-C and C-Heteroatom bonds. In the present work, a unique approach for the challenging electrophilic Au-catalyzed alpha-C-H bond functionalization of tertiary ...
David F. , León Rayo +4 more
core +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Remote C−H functionalization using radical translocating arylating groups
Nature Communications, 2018 Selective remote functionalization of aliphatic C(sp3)−H bonds is highly challenging and often requires transition metals and/or directing groups. Here, the authors show the γ-arylation of aliphatic alcohols via a two-step radical translocation and ...
Florian W. Friese +2 more
doaj +1 more source
Nature Communications, 2023 Asymmetric ring-opening (ARO) reactions, which can help quickly build molecular complexity, have not been extensively shown via β-oxygen elimination. Here, the authors report a cobalt(III)-catalyzed ARO reaction, providing mechanistic insights and the ...
Yang Zheng +4 more
doaj +1 more source
Frontiers in Chemistry, 2021 Selectively activating the distal inactive C-H bond for functionalization is one of the on-going challenge in organic synthetic chemistry. In recent years, benefiting from the development of selective synthesis methods, novel methodologies not only make ...
Huang Junrong +11 more
doaj +1 more source
Palladium-Catalyzed Directed para C-H Functionalization of Phenols
, 2016 Various practical methods for the selective C-H functionalization of the ortho and recently also of the meta position of an arene have already been developed.
BAG, S +17 more
core +1 more source
Radical‐Promoted Distal C‐H Functionalization of C(sp3) Centers with Fluorinated Moieties
, 2020 International audienceDue to their unique properties, fluorinated scaffolds are pivotal compounds in pharmaceuticals, agrochemicals and materials science.
Tatiana Besset +5 more
core +1 more source
Stereoselective C−B and C−H Bonds Functionalization of polyBorylated Alkenes [PDF]
, 2023 Alkenes are fundamental functional groups which feature in various materials and bioactive molecules; however, efficient divergent strategies for their stereodefined synthesis are difficult.
Narendra K., Vaishanv +3 more
core +1 more source