Results 71 to 80 of about 205,218 (235)

A new route towards uniformly functionalized single-layer graphene [PDF]

, 2010
It is shown, by DFT calculations, that the uniform functionalization of upper layer of graphite by hydrogen or fluorine does not change essentially its bonding energy with the underlying layers, whereas the functionalization by phenyl groups decreases ...
, Berger C, Boukhvalov D W, D W Boukhvalov, M I Katsnelson, Soler J M, Widenkvist E   +6 more
core   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Iridium-Catalyzed Silylation of Unactivated C-H Bonds. [PDF]

, 2019
The functionalization of primary C-H bonds has been a longstanding challenge in catalysis. Our group has developed a series of silylations of primary C-H bonds that occur with site selectivity and diastereoselectivity resulting from an approach to run ...
Hartwig, John F, Romero, Erik A
core  

Divergent and Stereoselective Synthesis of β-Silyl-α-Amino Acids through Palladium-Catalyzed Intermolecular Silylation of Unactivated Primary and Secondary C−H Bonds [PDF]

, 2016
A general and practical Pd^(II)-catalyzed intermolecular silylation of primary and secondary C−H bonds of α-amino acids and simple aliphatic acids is reported. This method provides divergent and stereoselective access to a variety of optical pure β-silyl-
Chen, Kai, Liu, Yan-Hua, Liu, Yue-Jin, Shi, Bing-Feng, Yan, Sheng-Yi, Zhang, Zhuo-Zhuo   +5 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Genetically Tunable Enzymatic C‒H Amidation for Lactam Synthesis [PDF]

, 2019
A major challenge in carbon‒hydrogen (C‒H) bond functionalization is to have the catalyst control precisely where a reaction takes place. Here we report engineered cytochrome P450 enzymes that perform unprecedented enantioselective C‒H amidation ...
Arnold, Frances H., Cho, Inha, Jia, Zhi-Jun   +2 more
core  

Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme [PDF]

, 2017
C–H bonds are ubiquitous structural units of organic molecules. Although these bonds are generally considered to be chemically inert, the recent emergence of methods for C–H functionalization promises to transform the way synthetic chemistry is performed.
A Sharma, Andrew R. Buller, C Liang, CC Farwell, Christopher K. Prier, CJC Whitehouse, CK Prier, DN Zalatan, ET Hennessy, EW Svastits, F Collet, Frances H. Arnold, G-D Roiban, H Li, HM Key, HML Davies, I Bertini, I Nägeli, J Yamaguchi, JA McIntosh, JD Bloom, JF Hartwig, JL Jeffrey, K Godula, LM Podust, M Barniol-Xicota, M Bordeaux, M Ochiai, M Schrewe, M Yamawaki, P Both, P Dydio, P Srivastava, PS Coelho, Q Michaudel, R Singh, RP Reddy, Ruijie K. Zhang, Sabine Brinkmann-Chen, T Ankner, TK Hyster, TK Hyster, TL Poulos, VB Urlacher, X Huang, Y Kohmura, Y Nishioka   +46 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Regioselective Access to Sultam Motifs through Cobalt-Catalyzed Annulation of Aryl Sulfonamides and Alkynes using an 8-Aminoquinoline Directing Group [PDF]

, 2015
The use of cobalt as catalyst in direct C[BOND]H activation protocols as a replacement for more expensive second row transition metals is currently attracting significant attention.
Ackermann, Ackermann, Ackermann, Andou, Beletskaya, Bernini, Casitas, Chen, Collins, Corbet, Daugulis, De Santis, Ding, Dong, Gensch, Godula, Grigorjeva, Grigorjeva, Grigorjeva, Guimond, He, Huestis, Hummel, Hyster, Ikemoto, Jia, Jiménez-Hopkins, Kajita, Kaneko, Larock, Lee, Li, Li, Li, Liu, Liu, Lombardino, Lyons, Ma, Majumdar, Merten, Morimoto, Mousseau, Pawar, Pham, Punji, Rakshit, Rassadin, Shah, Shi, Shilov, Shuklov, Song, Song, Stuart, Stuart, Sun, Sun, Suzuki, Tasker, Ueura, Ueura, Umeda, Wells, Wencel-Delord, Wendlandt, Wu, Wu, Wu, Wu, Wu, Yamaguchi, Yeung, Yoshino, Yu, Zhang, Zhang, Zhang, Zhao   +78 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source