Results 81 to 90 of about 205,218 (235)

Rh(III)-catalyzed directed C–H bond amidation of ferrocenes with isocyanates

Beilstein Journal of Organic Chemistry, 2012
[RhCp*(OAc)2(H2O)] [Cp* = pentamethylcyclopentadienyl] catalyzed the C–H bond amidation of ferrocenes possessing directing groups with isocyanates in the presence of 2 equiv/Rh of HBF4·OEt2.
Satoshi Takebayashi, Tsubasa Shizuno, Takashi Otani, Takanori Shibata   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Catalytic C−H Bond Functionalization with Palladium(II): Aerobic Oxidative Annulations of Indoles [PDF]

, 2003
A palladium-catalyzed aerobic oxidative annulation of indoles is described. We have demonstrated that a variety of factors influence these cyclizations, and in particular the electronic nature of the pyridine ligand is crucial. It is also remarkable that
Ferreira, Eric M., Stoltz, Brian M.
core   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Combined Oxypalladation/C-H Functionalization: Palladium(II)-Catalyzed Intramolecular Oxidative Oxyarylation of Hydroxyalkenes [PDF]

, 2011
An efficient protocol has been developed for the intramolecular oxidative oxyarylation using a Pd[superscript II]-catalyzed tandem oxypalladation/C-H functionalization strategy.
Alexanian, Beccalli, Cernak, Chen, Chen, Desai, Ferreira, Gligorich, Gómez-Gallego, He, Hegedus, Iglesias, Jensen, Jensen, Jensen, Li, Lira, Liu, Lu, Maimone, Matsuura, McDonald, Muzart, Muñiz, Nakhla, Nicolai, Nicolai, Nishimura, Nishimura, Pathak, Rosen, Rosewall, Schultz, Semmelhack, Semmelhack, Semmelhack, Shinohara, Sibbald, Sibbald, Smidt, Smidt, Stahl, Steinhoff, Streuff, Tietze, Torraca, Trend, Tsujihara, Vorogushin, Wang, Wang, Wolfe, Wolfe, Wu, Xiao, Yip, Yip, Yip, Zeni, Zhang   +59 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Palladium-catalyzed dual C–H or N–H functionalization of unfunctionalized indole derivatives with alkenes and arenes

Beilstein Journal of Organic Chemistry, 2012
This review highlights the development of palladium-catalyzed C–H and N–H functionalization reactions involving indole derivatives. These procedures require unactivated starting materials and are respectful of the basic principle of sustainable chemistry
Gianluigi Broggini, Egle M. Beccalli, Andrea Fasana, Silvia Gazzola   +3 more
doaj   +1 more source

Effect of Morphological Changes due to Increasing Carbon Nanoparticles Content on the Quasi-Static Mechanical Response of Epoxy Resin [PDF]

, 2018
Mechanical failure in epoxy polymer and composites leads them to commonly be referred to as inherently brittle due to the presence of polymerization-induced microcrack and microvoids, which are barriers to high-performance applications, e.g., in ...
Thakur, V. K., Yazdani Nezhad, H.
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source