Results 81 to 90 of about 206,495 (234)
Effect of Morphological Changes due to Increasing Carbon Nanoparticles Content on the Quasi-Static Mechanical Response of Epoxy Resin [PDF]
, 2018 Mechanical failure in epoxy polymer and composites leads them to commonly be referred to as inherently brittle due to the presence of polymerization-induced microcrack and microvoids, which are barriers to high-performance applications, e.g., in ...
Thakur, V. K., Yazdani Nezhad, H.
core +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A new route towards uniformly functionalized single-layer graphene [PDF]
, 2010 It is shown, by DFT calculations, that the uniform functionalization of upper layer of graphite by hydrogen or fluorine does not change essentially its bonding energy with the underlying layers, whereas the functionalization by phenyl groups decreases ...
+6 more
core +3 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2012 This review highlights the development of palladium-catalyzed C–H and N–H functionalization reactions involving indole derivatives. These procedures require unactivated starting materials and are respectful of the basic principle of sustainable chemistry
Gianluigi Broggini +3 more
doaj +1 more source
Targeted Derivatization of Medicines via Novel C-H Functionalization [PDF]
, 2015 The most ubiquitous bond in pharmaceuticals rests between carbon and hydrogen and until recently, however, the C-H bond has been ignored as a target for synthetic manipulation because of its inherently inert nature and the significant energetic ...
Chopko, Trevor
core
Vapor phase surface functionalization under ultra violet activation of parylene thin films grown by chemical vapor deposition [PDF]
, 2010 Various reactive gas phase treatments have been investigated as surface functionalization dry processes with the goal to improve the wettability of parylene C films, keeping good optical properties in the visible range. The films were grown on different
Maury, Francis +2 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Catalytic C−H Bond Functionalization with Palladium(II): Aerobic Oxidative Annulations of Indoles [PDF]
, 2003 A palladium-catalyzed aerobic oxidative annulation of indoles is described. We have demonstrated that a variety of factors influence these cyclizations, and in particular the electronic nature of the pyridine ligand is crucial. It is also remarkable that
Ferreira, Eric M., Stoltz, Brian M.
core +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source