Results 41 to 50 of about 310,106 (219)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Ethyl 2-[(2E)-4-decyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-ylidene]acetate
IUCrData, 2018 In the title compound, C22H32N2O3, the tetrahydroquinoxaline unit is planar. The ester substituent is nearly coplanar with this ring system as a result of an intramolecular N—H...O hydrogen bond.
Nadeem Abad +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
N,N-Dibutylanilinium hydrogen squarate
IUCrData, 2017 The title molecular salt, C14H24N+·C4HO4− [systematic name: N,N-dibutylbenzenaminium 2-hydroxy-3,4-dioxocyclobut-1-en-1-olate], is composed of a protonated N,N-dibutylaniline cation with a hydrogen squarate monoanion (common names).
Daron E. Janzen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Crystal structure of N-(quinolin-6-yl)hydroxylamine
Acta Crystallographica Section E, 2014 The title compound, C9H8N2O, crystallized with four independent molecules in the asymmetric unit. The four molecules are linked via one O—H...N and two N—H...N hydrogen bonds, forming a tetramer-like unit.
Anuruddha Rajapakse +5 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
2-Amino-4,6-dimethoxypyrimidin-1-ium p-toluenesulfonate
Acta Crystallographica Section E, 2011 In the title salt, C6H10N3O2+·C7H7O3S−, the 2-amino-4,6-dimethoxypyrimidinium cation interacts with the sulfonate group of the p-toluenesulfonate anion via a pair of N—H...O hydrogen bonds, forming a cyclic hydrogen-bonded ...
Packianathan Thomas Muthiah +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
2-(3-Benzoylthioureido)-3-phenylpropanoic acid
IUCrData, 2016 In the title compound, C17H16N2O3S, the phenylpropanoic acid and the benzoyl moieties adopt a cis–trans conformation, respectively, with respect to the thiono S atom across the C—N bonds.
Yan Yi Chong +2 more
doaj +1 more source