Results 61 to 70 of about 663,128 (258)

1-(4-Chloro­phen­yl)-4,4,6-trimethyl-3,4-dihydro­pyrimidine-2(1H)-thione [PDF]

, 2010
The dihydro­pyrimidine ring of the title compound, C13H15ClN2S, adopts an envelope conformation with five almost coplanar atoms (r.m.s. deviation = 0.054 Å) and the C atom bearing the two methyl substituents deviating from this plane by 0.441 (2) Å.
Aamer Saeed, Michael Bolte, Alam, Blessing, Kappe, Leite, Rovnyak, Sheldrick, Spek, Sriram, Swamy, Yamin   +11 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Ethyl 3-methyl-1-oxo-4H-1,4-benzothiazine-2-carboxylate monohydrate

IUCrData, 2018
The organic molecule in the title hydrate, C12H13NO3S·H2O, is folded across the S...N vector. Chains two molecules thick extending along the a-axis direction are formed by N—H...O and O—H...O hydrogen bonds.
Yamna Baryala, Youness El Bakri, El Hassane Anouar, Abdelfettahb Zerzouf, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

9-Aminoacridin-10-ium 4-aminobenzoate dihydrate [PDF]

, 2014
The asymmetric unit of the title hydrated salt, C13H11N2 +.-C7H6NO2-.2H2O, consists of two independent 9-aminoacridinium cations, two 4-aminobenzoate anions and four water molecules.
Arshad, Suhana, Dhanabalan, Nallathambi, Razak, Ibrahim Abdul, Santhanaraj, K. Joseph, Thanigaimani, Kaliyaperumal   +4 more
core   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

N,N-Dibutylanilinium hydrogen squarate

IUCrData, 2017
The title molecular salt, C14H24N+·C4HO4− [systematic name: N,N-dibutylbenzenaminium 2-hydroxy-3,4-dioxocyclobut-1-en-1-olate], is composed of a protonated N,N-dibutylaniline cation with a hydrogen squarate monoanion (common names).
Daron E. Janzen, Rita S. Majerle, Katie L. Novosad   +2 more
doaj   +1 more source

An ab initio and AIM investigation into the hydration of 2-thioxanthine [PDF]

, 2010
Background: Hydration is a universal phenomenon in nature. The interactions between biomolecules and water of hydration play a pivotal role in molecular biology. 2-Thioxanthine (2TX), a thio-modified nucleic acid base, is of significant interest as a DNA
Xiu-Xiang Yuan, Yan-Fang Wang, Xin Wang, Wenbo Chen, John S Fossey, Ning-Bew Wong, J Fitter, NJ Kim, W Pohil, B Bagchi, AP Sokolov, YG He, JH Hendricks, A Abo-Riziq, J Schiedt, W Chin, K Schoone, R Ramaekers, M Kabeláč, M Tho Nguyen, T Van Mourik, ES Kryachko, AK Chandra, AK Chandra, RB Zhang, T Frigato, AK Chandra, OV Shishkin, AK Chandra, S Kim, SA Trygubenko, M Hanus, M Hanus, J Rejnek, JD Zhang, RHD Lyngdoh, JD Gu, GA Spiller, K Miyamoto, K Yasui, Z Wang, DJ Darensbourg, A Dafali, OH Nielsen, CE Neunert, HG Mautner, LM Twanmoh, PU Civcir, BZ Li, G Stoychev, E Kulikowska, E Speina, H Tamta, K Papakostas, AE Reed, RWF Bader, C Møller, RG Parr, C Lee, AD Becke, SF Boys, R Ditchfield, K Wolinski, U Koch, PLA Popelier, F Biegler-König, F Biegler-König, MJ Frisch, GA Jeffrey, AK Rappé, JE Del Bene, ED Becker, P Hobza, XS Li, K Hermansson, B Blicharska, V Vailikhit, JE Del Bene, X Wang   +78 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Ethyl 2-[(2E)-4-decyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-ylidene]acetate

IUCrData, 2018
In the title compound, C22H32N2O3, the tetrahydroquinoxaline unit is planar. The ester substituent is nearly coplanar with this ring system as a result of an intramolecular N—H...O hydrogen bond.
Nadeem Abad, Youness El Bakri, Youssef Ramli, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source