Results 51 to 60 of about 310,106 (219)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Bis(2-amino-6-methylpyridinium) 3-nitrobenzene-1,2-dicarboxylate
IUCrData, 2016 In the title molecular salt, 2C6H9N2+·C8H3NO62−, the cations are protonated at their pyridine N atoms. The cations and anion are linked by N—H...O and C—H...O hydrogen bonds and a π–π interaction [centroid-to-centroid distance = 3.7299 (13) Å].
P. Sivakumar +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Crystal structure of 2-methyl-N-[(4-methylpyridin-2-yl)carbamothioyl]benzamide
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C15H15N3OS, there is an intramolecular N—H...O hydrogen bond and an intramolecular C—H...S hydrogen bond involving the C=O and C=S bonds which lie on opposite sides of the molecule.
Nadiah Ameram +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Methyl 2-{[3-(4,6-dimethoxypyrimidin-2-yl)ureido]sulfonylmethyl}benzoate
Acta Crystallographica Section E, 2008 In the title compound, C16H18N4O7S, a synthetic sulfonylurea herbicide, there are intramolecular N—H...N and C—H...O hydrogen bonds. Intermolecular N—H...O and C—H...O hydrogen bonds form centrosymmetric dimers. The dihedral angle
Deng-yu Wu +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
(E)-2-(3-Cinnamoylthioureido)acetic acid dimethyl sulfoxide disolvate
Acta Crystallographica Section E, 2011 In the title compound, C12H12N2O3S·2C2H6OS, the acetic acid and cinnamoyl groups adopt Z and E configurations, respectively, with respect to the thio group about the C—N bonds.
Mohammad B. Kassim +3 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
5-Amino-1H-1,2,4-triazol-4-ium hydrogen oxalate
Acta Crystallographica Section E, 2013 In the title salt, C2H5N4+·C2HO4−, the hydrogen oxalate anions form corrugated chains parallel to the c axis, linked by intermolecular O—H...O hydrogen bonds.
Mohamed Rzaigui +3 more
doaj +1 more source