Results 71 to 80 of about 663,128 (258)

Crystal structure of N-(quinolin-6-yl)hydroxylamine

Acta Crystallographica Section E, 2014
The title compound, C9H8N2O, crystallized with four independent molecules in the asymmetric unit. The four molecules are linked via one O—H...N and two N—H...N hydrogen bonds, forming a tetramer-like unit.
Anuruddha Rajapakse, Roman Hillebrand, Sarah M. Lewis, Zachary D. Parsons, Charles L. Barnes, Kent S. Gates   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

2-Amino-4,6-dimethoxypyrimidin-1-ium p-toluenesulfonate

Acta Crystallographica Section E, 2011
In the title salt, C6H10N3O2+·C7H7O3S−, the 2-amino-4,6-dimethoxypyrimidinium cation interacts with the sulfonate group of the p-toluenesulfonate anion via a pair of N—H...O hydrogen bonds, forming a cyclic hydrogen-bonded ...
Packianathan Thomas Muthiah, Sundaramoorthy Gomathi   +1 more
doaj   +1 more source

3-Methyl-1-{(E)-[1-(4-methylpyridin-2-yl)ethylidene]amino}thiourea: crystal structure and Hirshfeld surface analysis [PDF]

, 2018
The title disubstituted thiourea derivative, C10H14N4S, features an almost planar imine (E configuration, C3N) core flanked by thiourea (CN2S) and methylpyridyl (C5N) residues (each plane has a r.m.s. deviation of the respective fitted atoms of 0.0066 A
Che Nursarah Che AbdulRahman,, Jotani, Mukesh M., Lai, Lee Chin, M. Ibrahim M.Tahir,, Ravoof, Thahira Begum S. A., Tiekink, Edward R. T. *   +5 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

2-(3-Benzoylthioureido)-3-phenylpropanoic acid

IUCrData, 2016
In the title compound, C17H16N2O3S, the phenylpropanoic acid and the benzoyl moieties adopt a cis–trans conformation, respectively, with respect to the thiono S atom across the C—N bonds.
Yan Yi Chong, Mohamed Ibrahim Mohamed Tahir, Mohammad B. Kassim   +2 more
doaj   +1 more source

3-(3-Chloroanilino)-1-(3,5-dimethyl-1Hpyrazol-1-yl)propan-1-one [PDF]

, 2009
In the molecule of the title compound, C14H16ClN3O, the benzene and pyrazole rings are oriented at a dihedral angle of 3.50 (3)°. In the crystal structure, intermolecular N-H...O hydrogen bonds link the molecules into chains.
Aamer Saeed, Shahid Hussain, Michael Bolte, Akarca, Allen, Blessing, Elguero, Eriksson, Escolar, Mella, Penning, Saeed, Sheldrick, Spek   +13 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Bis(2-amino-6-methylpyridinium) 3-nitrobenzene-1,2-dicarboxylate

IUCrData, 2016
In the title molecular salt, 2C6H9N2+·C8H3NO62−, the cations are protonated at their pyridine N atoms. The cations and anion are linked by N—H...O and C—H...O hydrogen bonds and a π–π interaction [centroid-to-centroid distance = 3.7299 (13) Å].
P. Sivakumar, S. Sudhahar, S. Israel, G. Chakkaravarthi   +3 more
doaj   +1 more source

(η⁵-Cyclopentadienyl){[3-(2,2-dicyanoethenyl)bicyclo[2.2.1]hepta-2,5-dien-2-yl]ethynyl}(triphenylphosphine)nickel(II) [PDF]

, 2008
The title compound, [Ni(C₅H₅)(C₁₃H₇N₂)(C₁₈H₁₅P)] or (η⁵- C₅H₅)(PPh₃)Ni—C C—C₇H₆—C(H) C(CN)₂, contains an unusual disubstituted norbornadienyl (NBD) ligand containing ethynyl (–C C–) and dicyanovinyl [–C(H) C(CN)₂] groups.
John F. Gallagher, Peter Butler, A. R. Manning, Butler, Butler, Butler, Gallagher, McArdle, North, Sheldrick, Spek, Whittal, Whittal   +12 more
core   +2 more sources