ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Thin-film InGaAs metamorphic buffer for telecom C-band InAs quantum dots and optical resonators on GaAs platform. [PDF]
Nanophotonics, 2022 Sittig R +10 more
europepmc +1 more source
Design and Optimization of High-Responsivity High-Speed Ge/Si Avalanche Photodiode in the C+L Band [PDF]
, 2022 Chuan Li +4 more
openalex +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Characterization of Tiled Architecture for C-Band 1-Bit Beam-Steering Transmitarray. [PDF]
Sensors (Basel), 2021 Kozlov D +5 more
europepmc +1 more source
New approach for local C-band weather radar precipitation calibration
, 2020 José Roberto Ávila-Carrasco +3 more
openalex +2 more sources
Comparison of the Predictive Values of Absolute Neutrophil Count, Absolute Band Count, and Toxic Granulation of Neutrophils with Serum Levels of C-reactive Protein for the Diagnosis of Bacterial Infections [PDF]
, 2018 Seyyed Hamid Hashemi +3 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Deterministic and highly indistinguishable single photons in the telecom C-band. [PDF]
Nat CommunHauser N +10 more
europepmc +1 more source
Wave discrimination at C-band frequencies in microstrip structures inspired by electromagnetically induced transparency. [PDF]
Sci Rep, 2021 Jabbar A +4 more
europepmc +1 more source