Results 101 to 110 of about 672,685 (308)

Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis [PDF]

, 2012
Current macrophage phenotype classifications are based on distinct in vitro culture conditions that do not adequately mirror complex tissue environments.
Weidenbusch, Marc, Anders, Hans-Joachim
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

IL-1β Induced Cytokine Expression by Spinal Astrocytes Can Play a Role in the Maintenance of Chronic Inflammatory Pain

Frontiers in Physiology, 2020
It is now widely accepted that the glial cells of the central nervous system (CNS) are key players in many processes, especially when they are activated via neuron-glia or glia-glia interactions.
Andrea Gajtkó, Erzsébet Bakk, Krisztina Hegedűs, László Ducza, Krisztina Holló   +4 more
doaj   +1 more source

MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7

Breast Cancer Research, 2012
IntroductionC-C chemokine receptor type 7 (CCR7) plays an important role in chemotactic and metastatic responses in various cancers, including breast cancer.
Seok-Jun Kim, Ji‐Young Shin, Kang-Duck Lee, Y. Bae, K. Sung, S. Nam, Kyung-Hee Chun   +6 more
semanticscholar   +1 more source

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]

, 2015
G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie, Graeme eMilligan, Nina eDivorty, Nina eDivorty, Stuart A. Nicklin   +4 more
core   +3 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Does CCR5 gene-D32 deletion protect C.trachomatis infected Indian women from tubal pathology?

Microbiology Research, 2011
Deletion in chemokine receptor CCR5 gene is reported to prevent development of tubal pathology among Dutch Caucasian C. trachomatis infected women. Hence, a pilot study was undertaken, to evaluate the involvement of CCR5 gene in tubal pathology among ...
Jayanti Mania-Pramanik, Shilpa C. Kerkar, Anjali Vallabhadas, Pratibha B Mehta, Vinita Salvi   +4 more
doaj   +1 more source

Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration. [PDF]

, 2017
Hereditary epidermolysis bullosa (EB) is associated with skin blistering and the development of chronic nonhealing wounds. Although clinical studies have shown that cell-based therapies improve wound healing, the recruitment of therapeutic cells to ...
Alexeev, Vitali, Fortuna, Giulio, Igoucheva, Olga, Mukhtarzada, Lila, Palisson, Francis, Salas-Alanis, Julio Cesar, South, Andrew P., Uitto, Jouni   +7 more
core   +1 more source

Serum protein fingerprinting by PEA immunoassay coupled with a pattern-recognition algorithms distinguishes MGUS and multiple myeloma [PDF]

, 2016
Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored.
Fillerová, Regina, Gajdoš, Petr, Kriegová, Eva, Krömer, Pavel, Kudělka, Miloš, Minařík, Jiří, Papajík, Tomáš, Pika, Tomáš, Schneiderová, Petra, Ščudla, Vlastimil   +9 more
core   +1 more source

A Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis

Arthritis Research & Therapy
Background The objective of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑06835375, a potent selective afucosyl immunoglobulin G1 antibody targeting C-X-C chemokine receptor type 5 (CXCR5) that ...
Stanley B. Cohen, J. Beebe, V. Chindalore, Shunjie Guan, M. Hassan-Zahraee, Madhurima Saxena, Li Xi, Craig L Hyde, S. Koride, Robert Levin, S. Lubaczewski, M. Salganik, Abigail Sloan, Erin Stevens, E. Peeva, Michael S. Vincent, David A. Martin, M. Chu   +17 more
semanticscholar   +1 more source