Results 231 to 240 of about 672,685 (308)

Targeting of Kaposi's sarcoma-associated herpesvirus by immunotoxins directed against the viral G protein-coupled receptor, ORF74.

Biomed Pharmacother
Kildedal DF, Drzazga AK, Sharma A, Berg C, Winther AN, Krogh-Hansen L, Gustavsson M, Kragelund BB, Våbenø J, Lagunoff M, Tsutsumi N, Kledal TN, Jeppesen MG, Rosenkilde MM.   +13 more
europepmc   +1 more source

Macrophage Plasticity and Regulatory Networks During the Transition from Inflammation to Fibrosis in the Kidney. [PDF]

Life (Basel)
Moon Y, Hong J, Chung J, Baek JH.
europepmc   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Inflammation and Diabetic Kidney Disease. [PDF]

Int J Mol Sci
Zhang RM, Caramori ML.
europepmc   +1 more source

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

Proceedings of the National Academy of Sciences of the United States of America, 2013
J. Quoyer, Jay M. Janz, Jiansong Luo, Yong Ren, Sylvain Armando, V. Lukashova, J. Benovic, K. Carlson, Stephen W. Hunt, M. Bouvier   +9 more
semanticscholar   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

CXCR4 expression serves as a promising candidate target in the treatment of breast cancer. [PDF]

Medicine (Baltimore)
Liao F, Huang J, Zhang Y.
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

The Role of Fibroblasts in Atopic Dermatitis: Establishing Proinflammatory Microenvironments and Mediating Cellular Crosstalk. [PDF]

J Inflamm Res
Yao WH, Sun C, Su Z, Wang P, Zeng YP.
europepmc   +1 more source