Results 71 to 80 of about 672,685 (308)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

CCL20-CCR6 axis modulated traumatic brain injury-induced visual pathologies

Journal of Neuroinflammation, 2019
Background Traumatic brain injury (TBI) is a major cause of death and disability in the USA and the world; it constitutes 30% of injury-related deaths (Taylor et al., MMWR Surveill Summ 66:1-16, 2017).
Mahasweta Das, Xiaolan Tang, Jung Yeon Han, Karthick Mayilsamy, Elspeth Foran, Manas R. Biswal, Radouil Tzekov, Shyam S. Mohapatra, Subhra Mohapatra   +8 more
doaj   +1 more source

Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis

The Journal of Clinical Investigation, 2023
Recognition of pathogen-associated molecular patterns can trigger the inositol-requiring enzyme 1 α (IRE1α) arm of the endoplasmic reticulum (ER) stress response in innate immune cells.
Deepika Awasthi, Sahil Chopra, Byuri A. Cho, Alexander Emmanuelli, Tito A. Sandoval, Sung-Min Hwang, Chang-Suk Chae, Camilla Salvagno, Chen Tan, Liliana Vasquez-Urbina, Jose J. Fernandez Rodriguez, Sara F. Santagostino, Takao Iwawaki, E. Alfonso Romero-Sandoval, Mariano Sanchez Crespo, Diana K. Morales, Iliyan D. Iliev, Tobias M. Hohl, Juan R. Cubillos-Ruiz   +18 more
doaj   +1 more source

Characteristics of Allergic Pulmonary Inflammation in CXCR3Knockout Mice Sensitized and Challenged with House Dust Mite Protein. [PDF]

PLoS ONE, 2016
Chemokine C-X-C motif receptor 3 (CXCR3) is a chemokine receptor that is mainly expressed by activated T lymphocytes. T cells play important roles in allergic pulmonary inflammation, which is a hallmark of asthma and elicits the localized accumulation of
Zhongjuan Liu, Huaxia Chen, Xiaolan Chen, Jinming Gao, Zijian Guo   +4 more
doaj   +1 more source

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses [PDF]

, 2017
CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target.
A Mantovani, A Rot, A Rot, A Zlotnik, A Zlotnik, AA Filardy, AE Cardona, AEI Proudfoot, C Schinke, D Marvel, DI Gabrilovich, F Bachelerie, F Balkwill, F Porcheray, F Sallusto, FR Balkwill, G Cacalano, H Saiwai, HM Baldwin, J Dalli, J Schindelin, J Yang, J-I Youn, J-I Youn, K Kishida, KM Hertzer, L Liu, M-C Lo, MK Ho, O Soehnlein, P Ranganathan, P Scapini, RA Navarro-Xavier, RM Devalaraja, S Milatovic, T Jamieson, T Jamieson, T Kakinuma, TJ Schall   +38 more
core   +1 more source

C‐C Chemokine Receptor Type 5 (CCR5)‐Mediated Docking of Transferred Tregs Protects Against Early Blood‐Brain Barrier Disruption After Stroke

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background Despite recent evidence demonstrating a potent protective effect of adoptively transferred regulatory T cells (Tregs) in ischemic stroke, the mechanism for Treg mobilization and activation in the ischemic brain is, remarkably, unknown.
Peiying Li, Long Wang, Yuxi Zhou, Yu Gan, Wen Zhu, Yuguo Xia, Xiaoyan Jiang, Simon C Watkins, A. Vázquez, A. Thomson, Jun Chen, Weifeng Yu, Xiaoming Hu   +12 more
semanticscholar   +1 more source

Antifibrogenic effects of C‐C chemokine receptor type 2 antagonist in a bleomycin‐induced scleroderma model

Experimental Dermatology, 2020
There have been several studies on the role of the monocyte chemotactic protein‐1/C‐C chemokine receptor type 2 (CCR2) signalling pathway in fibrotic diseases, which identified the blockade of this pathway as a potential therapeutic target for treating ...
M. Ishikawa, Toshiyuki Yamamoto
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Defining a non-eosinophilic inflammatory subtype in COPD: the role of CXCL9 and type 1 immune responses

Frontiers in Immunology
BackgroundC–X–C motif chemokine ligand 9 (CXCL9) is induced by the interferon-γ response, and its receptor, C–X–C motif chemokine receptor 3, is a well-established marker of T-helper 1 (Th1) cells, which play an essential role in type 1 immune responses.
Yin Chengsheng, Song Jiacui, Takehiro Hasegawa, Ling Yao, Takami Kondo, Li Huiping   +5 more
doaj   +1 more source

Putative transcriptomic biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients. [PDF]

PLoS ONE, 2014
Mood disorders consist of two etiologically related, but distinctly treated illnesses, major depressive disorder (MDD) and bipolar disorder (BPD). These disorders share similarities in their clinical presentation, and thus show high rates of misdiagnosis.
Timothy R Powell, Peter McGuffin, Ursula M D'Souza, Sarah Cohen-Woods, Georgina M Hosang, Charlotte Martin, Keith Matthews, Richard K Day, Anne E Farmer, Katherine E Tansey, Leonard C Schalkwyk   +10 more
doaj   +1 more source