Results 231 to 240 of about 24,734 (337)

Biofilm Dispersal in <i>Bacillus velezensis</i> FZB42 Is Regulated by the Second Messenger c-di-GMP. [PDF]

Microorganisms
Zhang M, Wu S, Chen P, Shao L, Shen Z, Zhao Y.   +5 more
europepmc   +1 more source

The rising tide: Trends in induction of labor at term over a 5‐year period at a single centre

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 383-390, April 2025.
Abstract Objective Induction of labor (IOL) is a controversial topic in contemporary obstetric practice, with some suggesting that the increase in elective induction (eIOL) as a potential contributor to increasing cesarean delivery (CD) rates. The objectives of this single‐center study were to examine the rates of IOL, trends in indications for IOL ...
Sarah M. Nicholson, Susan Hatt, Etaoin M. Kent, Michael P. Geary, Patrick Dicker, Zara E. Molphy, Karen Flood, Fergal D. Malone   +7 more
wiley   +1 more source

c-di-GMP is required for swarming in <i>E. coli</i>, producing colanic acid that acts as surfactant. [PDF]

mBio
Hwang Y, Perez M, Holzel R, Harshey RM.
europepmc   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Review of: "Polyethylene Terephthalate (PET) Primary Degradation Products Affect c-di-GMP-, cAMP-Signaling, and Quorum Sensing (QS) in Vibrio gazogenes DSM 21264" [PDF]

Alessandro Satta
openalex   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

The Immunoregulatory and Hematopoietic Effects of Momelotinib in a Murine Bone Marrow Failure Model

Journal of Clinical Laboratory Analysis, EarlyView.
Momelotinib, a selective small‐molecule inhibitor of JAK1/2 and the bone morphogenic protein receptor kinase activin A receptor type I (ACVR1), exerts its effects by inhibiting the overactivation of the BMP/ACVR1/SMAD signaling pathway. This inhibition reduces hepcidin production in hepatocytes, and reduces inflammation, aberrant cytokine signaling ...
Yue Zhang, Huiqin Zhang, Naibo Hu, Liping Yang, Yumei Liu, Liyan Yang, Xifeng Dong, Huaquan Wang   +7 more
wiley   +1 more source

A novel two-component system contributing the catabolism of c-di-GMP influences virulence in Aeromonas veronii. [PDF]

Front Microbiol
Liu C, Shao J, Ma X, Tang Y, Li J, Li H, Chi X, Liu Z.   +7 more
europepmc   +1 more source

Cyclic-di-GMP binding induces structural rearrangements in the PlzA and PlzC proteins of the Lyme disease and relapsing fever spirochetes: a possible switch mechanism for c-di-GMP-mediated effector functions [PDF]

, 2016
Katherine L. Mallory, Daniel P. Miller, Lee D. Oliver, John C. Freedman, Jessica L. Kostick-Dunn, Jason A. Carlyon, James Marion, Jessica K. Bell, Richard T. Marconi   +8 more
openalex   +1 more source

Ginsenoside Rb1 Targets the HRD1‐STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic representation of the proposed mechanism of action for Ginsenoside Rb1. Suppression of HRD1 expression in VSMCs cholesterol stimulation, leading to ER stress (BiP/XBP1s upregulation), STING pathway activation, ROS accumulation (including mitochondrial ROS), and ultimately, VSMC senescence.
Haiming Niu, Yingzhang Cai, Conghui Yu, Ning Lin, Miaolian Chen, Linli Wang   +5 more
wiley   +1 more source