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Identification of c-di-GMP-Responsive Riboswitches
2017Bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) is an important signaling molecule for community behavior control, cell morphogenesis, and virulence in bacteria. In addition to protein effectors, this second messenger binds RNA molecules that act as riboswitches to control target gene expression.
Peltier, Johann, Soutourina, Olga
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Biofilm control by interfering with c-di-GMP metabolism and signaling
Biotechnology Advances, 2022Biofilm formation and biofilm-induced biodeterioration of surfaces have deeply affected the life of our community. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small nucleotide-based signaling molecule in bacteria, which functions as a second messenger mediating a wide range of bacterial processes, such as cell motility, biofilm formation ...
Xiaobo, Liu +3 more
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Prevailing Concepts of c-di-GMP Signaling
2009Recently, the list of ubiquitous bacterial secondary messengers which include cAMP and ppGpp has been extended by 3',5'-cyclic diguanylic acid (c-di-GMP). C-di-GMP metabolism is tuned by the tightly controlled activity of diguanylate cyclases and c-di-GMP-specific phosphodiesterases.
Ute, Römling, Roger, Simm
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Synthesis and Characterization of C8 Analogs of c-di-GMP
Nucleosides, Nucleotides and Nucleic Acids, 2011We have synthesized five analogs of c-di-GMP with different substituents at the guanine C8 position, to study their effects on the metal-dependent polymorphism we had previously demonstrated for the parent compound. Of these, only the K(+) salt of c-di-Br-GMP, 2, forms higher order complexes, predominantly two different syn octamolecular ones. Its Na(+)
Elizabeth, Veliath +3 more
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2017
The second messenger, cyclic diguanylate (c-di-GMP), regulates a variety of bacterial cellular and social behaviors. A key determinant of c-di-GMP levels in cells is its degradation by c-di-GMP-specific phosphodiesterases (PDEs). Here, we describe an assay to determine c-di-GMP degradation rates in vitro using 2'-O-(N'-methylanthraniloyl)-cyclic ...
Dorit, Eli +4 more
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The second messenger, cyclic diguanylate (c-di-GMP), regulates a variety of bacterial cellular and social behaviors. A key determinant of c-di-GMP levels in cells is its degradation by c-di-GMP-specific phosphodiesterases (PDEs). Here, we describe an assay to determine c-di-GMP degradation rates in vitro using 2'-O-(N'-methylanthraniloyl)-cyclic ...
Dorit, Eli +4 more
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High-specificity local and global c-di-GMP signaling
Trends in Microbiology, 2021The striking multiplicity, signal input diversity, and output specificity of c-di-GMP signaling proteins in many bacteria has brought second messenger signaling back onto the agenda of contemporary microbiology. How can several signaling pathways act in parallel in a specific manner if all of them use the same diffusible second messenger present at a ...
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[Progress in c-di-GMP inhibitors].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2018The cyclic dinucleotide c-di-GMP is known as an important second messenger in bacteria, which controls various important cellular processes, such as cell differentiation, biofilm formation and virulence factors production. It is extremely vital for the development of new antibacterial agents by virtue of blocking c-di-GMP signal conduction.
Xuwen, Xiang +4 more
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c-di-GMP-mediated regulation of virulence and biofilm formation
Current Opinion in Microbiology, 2007It is now apparent that the signaling molecule 3',5'-cyclic diguanylic acid (c-di-GMP) is a central regulator of the prokaryote biofilm lifestyle and recent evidence also links this molecule to virulence. Environmentally responsive signal transduction systems that control expression and/or activity of the enzymes (GGDEF and EAL domain containing ...
Peggy A, Cotter, Scott, Stibitz
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c-di-GMP signalling and the regulation of developmental transitions in streptomycetes
Nature Reviews Microbiology, 2015The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation.
Matthew J, Bush +4 more
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Regulation by c-di-GMP in Myxococcus xanthus
2020Myxococcus xanthus has a complex lifecycle that is regulated by nutrient availability. In the presence of nutrients, M. xanthus cells grow, divide, and move to assemble into colonies that feed cooperatively either saprophytically or on prey. In response to starvation, a developmental program is initiated that culminates in formation of multicellular ...
Perez-Burgos, M., Sogaard-Andersen, L.
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