Precision Radiation Oncology, EarlyView.This study develops a method combining radiochromic film and image processing to assess HDR brachytherapy source accuracy and linearity, achieving high precision and efficiency . Abstract Purpose To develop and validate a fully automated quality assurance method for high‐dose rate (HDR) brachytherapy, enabling the precise evaluation of source dwell ...
Qingqing Yuan +4 more
wiley +1 more source
Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates. [PDF]
NPJ Biofilms MicrobiomesCai YM +5 more
europepmc +1 more source
Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review
Phytotherapy Research, EarlyView.ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley +1 more source
c-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa. [PDF]
mSphereFeng Q +5 more
europepmc +1 more source
Ashwagandha: Is It Safe? Part 1: A Regulatory Review
Phytotherapy Research, EarlyView.ABSTRACT Over the last decade, ashwagandha (Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler +5 more
wiley +1 more source
Insertion of a Divergent GAF-like Domain Defines a Novel Family of YcgR Homologues That Bind c-di-GMP in Leptospirales. [PDF]
ACS OmegaVisnardi AB +16 more
europepmc +1 more source
Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A
Phytotherapy Research, EarlyView.ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen +16 more
wiley +1 more source
Myricetin Potentiates Antibiotics Against Resistant <i>Pseudomonas aeruginosa</i> by Disrupting Biofilm Formation and Inhibiting Motility Through FimX-Mediated c-di-GMP Signaling Interference. [PDF]
Biology (Basel)Zeng D +12 more
europepmc +1 more source
Thunderbird International Business Review, EarlyView.ABSTRACT The last few years have seen a reemergence in the awareness of virtual worlds among practitioners and academics. Driven by tech giants' investments, the Metaverse is considered by some as an unprecedented revolutionary technology with the potential to unlock an entire gamut of new unexplored opportunities for both companies and individuals ...
Giulio Ferrigno +2 more
wiley +1 more source
The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li +4 more
wiley +1 more source