Results 261 to 270 of about 459,122 (273)

Design and Synthesis of Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors.

Journal of Medicinal Chemistry, 2021
The formation of biofilms by clinical pathogens typically leads to chronic and recurring antibiotic-resistant infections. High cellular levels of cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger of bacteria, have been proven to be ...
Teng-Fei Xuan, Zi-Qiang Wang, Jun Liu, Haizhen Yu, Qianqian Lin, Wei-Min Chen, Jing Lin   +6 more
semanticscholar   +1 more source

Structural and mechanistic determinants of c-di-GMP signalling

Nature Reviews Microbiology, 2009
Bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) is a ubiquitous second messenger that regulates cell surface-associated traits in bacteria. Components of this regulatory network include GGDEF and EAL domain-containing proteins that determine the cellular concentrations of c-di-GMP by mediating its synthesis and degradation, respectively.
Schirmer, Tilman, Jenal, Urs
openaire   +4 more sources

Prevailing Concepts of c-di-GMP Signaling

2009
Recently, the list of ubiquitous bacterial secondary messengers which include cAMP and ppGpp has been extended by 3',5'-cyclic diguanylic acid (c-di-GMP). C-di-GMP metabolism is tuned by the tightly controlled activity of diguanylate cyclases and c-di-GMP-specific phosphodiesterases.
Ute Römling, Roger Simm
openaire   +3 more sources

STING Activator c-di-GMP-Loaded Mesoporous Silica Nanoparticles Enhance Immunotherapy Against Breast Cancer.

ACS Applied Materials and Interfaces, 2020
Reversing the immunosuppressive tumor microenvironment (TME) is a strategic initiative to sensitize cancer immunotherapy. Emerging evidence shows that cyclic diguanylate monophosphate (c-di-GMP or cdG) can induce the stimulator of interferon genes (STING)
Yi-Ping Chen, Li Xu, Tao-Wei Tang, Cheuh-Hsuan Chen, Quan-hong Zheng, Tsang‐Pai Liu, C. Mou, Cheng-Hsun Wu, Si-Han Wu   +8 more
semanticscholar   +1 more source

[Structure and function of c-di-GMP riboswitches].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2017
Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous nucleotide second messenger present in a wide variety of bacteria. It regulates many important bacterial physiological functions such as biofilm formation, motility, adhesion, virulence and extracellular polysaccharide synthesis.
Xinfeng Li, Jinfeng Xiao, Jin He, Fang Chen   +3 more
openaire   +2 more sources

Measuring Cyclic Diguanylate (c-di-GMP)-Specific Phosphodiesterase Activity Using the MANT-c-di-GMP Assay

2017
The second messenger, cyclic diguanylate (c-di-GMP), regulates a variety of bacterial cellular and social behaviors. A key determinant of c-di-GMP levels in cells is its degradation by c-di-GMP-specific phosphodiesterases (PDEs). Here, we describe an assay to determine c-di-GMP degradation rates in vitro using 2'-O-(N'-methylanthraniloyl)-cyclic ...
Dorit Eli, Joe J. Harrison, Trevor E. Randall, Henrik Almblad, Ehud Banin   +4 more
openaire   +3 more sources

Streptomyces teams up with c-di-GMP [PDF]

Nature Reviews Microbiology, 2014
A new study shows that a unique tetrameric form of c-di-GMP controls development in Streptomyces venezuelae by mediating dimerization of a transcription factor.
openaire   +2 more sources

Synthesis and Characterization of C8 Analogs of c-di-GMP

Nucleosides, Nucleotides and Nucleic Acids, 2011
We have synthesized five analogs of c-di-GMP with different substituents at the guanine C8 position, to study their effects on the metal-dependent polymorphism we had previously demonstrated for the parent compound. Of these, only the K(+) salt of c-di-Br-GMP, 2, forms higher order complexes, predominantly two different syn octamolecular ones. Its Na(+)
Elizabeth, Veliath, Seho, Kim, Barbara L, Gaffney, Roger A, Jones   +3 more
openaire   +2 more sources

c-di-GMP signalling and the regulation of developmental transitions in streptomycetes

Nature Reviews Microbiology, 2015
The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation.
Susan Schlimpert, Natalia Tschowri, Matthew J. Bush, Mark J. Buttner, Klas Flärdh   +4 more
openaire   +3 more sources

c-di-GMP-mediated regulation of virulence and biofilm formation

Current Opinion in Microbiology, 2007
It is now apparent that the signaling molecule 3',5'-cyclic diguanylic acid (c-di-GMP) is a central regulator of the prokaryote biofilm lifestyle and recent evidence also links this molecule to virulence. Environmentally responsive signal transduction systems that control expression and/or activity of the enzymes (GGDEF and EAL domain containing ...
Scott Stibitz, Peggy A. Cotter
openaire   +3 more sources