Results 311 to 320 of about 24,734 (337)

Differential binding of 2′-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins

Mol. BioSyst., 2012
C-di-GMP has emerged as a signalling molecule that regulates a variety of processes in several bacteria; therefore there is interest in the development of biotinylated analogs for the identification of binding partners. No detailed study has been done to evaluate if biotinylated analogs of c-di-GMP are capable of binding to c-di-GMP receptors.
Yiling, Luo, Jie, Zhou, Sarah K, Watt, Vincent T, Lee, T Kwaku, Dayie, Herman O, Sintim   +5 more
openaire   +2 more sources

High-specificity local and global c-di-GMP signaling

Trends in Microbiology, 2021
The striking multiplicity, signal input diversity, and output specificity of c-di-GMP signaling proteins in many bacteria has brought second messenger signaling back onto the agenda of contemporary microbiology. How can several signaling pathways act in parallel in a specific manner if all of them use the same diffusible second messenger present at a ...
openaire   +2 more sources

[Progress in c-di-GMP inhibitors].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2018
The cyclic dinucleotide c-di-GMP is known as an important second messenger in bacteria, which controls various important cellular processes, such as cell differentiation, biofilm formation and virulence factors production. It is extremely vital for the development of new antibacterial agents by virtue of blocking c-di-GMP signal conduction.
Xuwen, Xiang, Xingyu, Liu, Hui, Tao, Zining, Cui, Lianhui, Zhang   +4 more
openaire   +1 more source

Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2′-F-c-di-GMP

Bioorganic & Medicinal Chemistry, 2013
Cyclic-di-GMP (c-di-GMP) is a central regulator of bacterial behavior. Various studies have implicated c-di-GMP in biofilm formation and virulence factor production in multitudes of bacteria. Hence it is expected that the disruption of c-di-GMP signaling could provide an effective means to disrupt biofilm and/or virulence factor formation in several ...
Jie, Zhou, Sarah, Watt, Jingxin, Wang, Shizuka, Nakayama, David A, Sayre, Yiu-Fai, Lam, Vincent T, Lee, Herman O, Sintim   +7 more
openaire   +2 more sources

Emerging paradigms for PilZ domain-mediated C-di-GMP signaling

Biochemical Society Transactions, 2019
Abstract PilZ domain-containing proteins constitute a large family of bacterial signaling proteins. As a widely distributed protein domain for the binding of the second messenger c-di-GMP, the canonical PilZ domain contains a set of motifs that define the binding site for c-di-GMP and an allosteric switch for propagating local ...
Qing Wei Cheang, Lingyi Xin, Rachel Yuen Fong Chea, Zhao-Xun Liang   +3 more
openaire   +2 more sources

c-di-GMP-mediated regulation of virulence and biofilm formation

Current Opinion in Microbiology, 2007
It is now apparent that the signaling molecule 3',5'-cyclic diguanylic acid (c-di-GMP) is a central regulator of the prokaryote biofilm lifestyle and recent evidence also links this molecule to virulence. Environmentally responsive signal transduction systems that control expression and/or activity of the enzymes (GGDEF and EAL domain containing ...
Peggy A, Cotter, Scott, Stibitz
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c-di-GMP Displays A Monovalent Metal Ion-Dependent Polymorphism

Journal of the American Chemical Society, 2004
Cyclic diguanosine monophosphate (c-di-GMP) is known to be an important signaling molecule that regulates the formation of bacterial biofilms. We demonstrate here by UV, CD, and NMR that it displays a surprising polymorphism that varies with the monovalent counterion and is consistent with the formation of a G-quartet structure in K+ and a stacked ...
Zhaoying, Zhang, Barbara L, Gaffney, Roger A, Jones   +2 more
openaire   +2 more sources

Synthesis and Characterization of C8 Analogs of c-di-GMP

Nucleosides, Nucleotides and Nucleic Acids, 2011
We have synthesized five analogs of c-di-GMP with different substituents at the guanine C8 position, to study their effects on the metal-dependent polymorphism we had previously demonstrated for the parent compound. Of these, only the K(+) salt of c-di-Br-GMP, 2, forms higher order complexes, predominantly two different syn octamolecular ones. Its Na(+)
Elizabeth, Veliath, Seho, Kim, Barbara L, Gaffney, Roger A, Jones   +3 more
openaire   +2 more sources

Cyclin-like function of bacterial c-di-GMP

Science Signaling, 2015
The bacterial second messenger c-di-GMP controls cell cycle progression.
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[Structure and function of c-di-GMP riboswitches].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2018
Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous nucleotide second messenger present in a wide variety of bacteria. It regulates many important bacterial physiological functions such as biofilm formation, motility, adhesion, virulence and extracellular polysaccharide synthesis.
Xinfeng, Li, Fang, Chen, Jinfeng, Xiao, Jin, He   +3 more
openaire   +1 more source