Results 311 to 320 of about 470,032 (357)

Extrachromosomal Circular DNA: Emerging Insights Into Cardiovascular Disease Mechanisms and Biomarker Potential

iLABMED, EarlyView.
Extrachromosomal circular DNA (eccDNA) has quite recently turned out to be a cardinal component in cardiovascular diseases (CVD), governing the gene expression and mechanisms of disease causation. Studies indicated an upregulation of eccDNA in pulmonary arterial hypertension (PAH), which makes it strikingly potential as a sensitive and specific ...
Saim Mahmood Khan, Jawairya Muhammad Hussain, Surraiya Riaz Mahmood Khan, Bushra Nadeem, Tahniyat Naseem, Hammad Jawed, Aina Lashari   +6 more
wiley   +1 more source

A c-di-GMP binding effector STM0435 modulates flagellar motility and pathogenicity in Salmonella. [PDF]

Virulence
Dai Y, Liu R, Yue Y, Song N, Jia H, Ma Z, Gao X, Zhang M, Yuan X, Liu Q, Liu X, Li B, Wang W.   +12 more
europepmc   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

<i>Cronobacter sakazakii</i> lysozyme inhibitor LprI mediated by HmsP and c-di-GMP is essential for biofilm formation and virulence. [PDF]

Appl Environ Microbiol
Ji X, Fan D, Wang J, Zhang B, Hu Y, Lv H, Wu J, Sun Y, Liu J, Zhang Y, Wang S.   +10 more
europepmc   +1 more source

Lactobacillus johnsonii‐FM1 modulates gut microbiota and secretes anticancer metabolite vanillic acid to inhibit colorectal tumorigenesis

iMetaOmics, EarlyView.
Lactobacillus johnsonii‐FM1 alleviates colorectal tumorigenesis in both ApcMin/+ and azoxymethane/dextran sulfate sodium mouse models by enriching beneficial gut microbiota, restoring epithelial barrier integrity, suppressing cancer cell proliferation, and promoting apoptosis.
Wei Lyu, Lu Chen, De‐Feng Li, Shu‐Ying Li, Qian Dai, Hong‐Li Zhou, Yan‐Yan Liu, Jian‐Yun Zhou, Xin‐Jun Liang, Ling Wang   +9 more
wiley   +1 more source

Autoinducer-2 enhances the defense of <i>Vibrio furnissii</i> against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system. [PDF]

mBio
Zhang H, Zhao W, Yang W, Zhang H, Qian X, Sun K, Yang Q, Shen X, Zhang L.   +8 more
europepmc   +1 more source

Performance Evaluation of a New HRD Assay (HRDsig) in Ovarian Carcinomas in Australia

Journal of Clinical Laboratory Analysis, EarlyView.
In this study we have evaluated the performance of a new HRD assay (HRDsig) against two accredited HRD assays, as well as against commercial controls and inter‐laboratory comparison samples. HRDsig has demonstrated a high concordance rate for determining HRD status in ovarian carcinomas.
Pranav Dorwal, Liyan Song, Priscillia Siswara, Amit Kumar, Julie Robin, Noel Djitro, Anna Fong Na Goh, Ravikiran Vedururu, Bin Yuan, Ashleigh Levine, Suzanne Svobodova, Beena Kumar   +11 more
wiley   +1 more source

Combining Correlative Cryogenic Fluorescence and Electron Microscopy and Correlative Cryogenic Super‐Resolution Fluorescence and X‐Ray Tomography—Novel Complementary 3D Cryo‐Microscopy Across Scales to Reveal Nanoparticle Internalization Into Cancer Cells

Microscopy Research and Technique, EarlyView.
A newly established 3D correlative cryogenic fluorescence microscopy, focused ion beam scanning electron microscopy, and soft x‐ray tomography workflow allowed for enough contrast and resolution to quantify the intracellular uptake of zirconyl‐containing inorganic–organic hybrid nanoparticles as a novel chemotherapeutic drug delivery system into ...
Pavitra Sokke Rudraiah, Louisa Herbsleb, Michaela Salakova, Henriette Gröger, Anna Maria Steyer, Frauke Alves, Claus Feldmann, Andreas Walter   +7 more
wiley   +1 more source

Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Conventional Magnetic Resonance Imaging (MRI) offers limited sensitivity for direct metabolic and molecular imaging using non‐proton nuclei due to low thermal nuclear spin polarization. Hyperpolarization (HP) technologies increase nuclear spin polarization by several orders of magnitude, overcoming this limitation to enable in vivo studies of ...
Alixander S. Khan, Christoffer Laustsen
wiley   +1 more source

Periodontitis in patients with severe erectile dysfunction undergoing penile prosthesis implantation: Clinical and immunohistochemical study

Journal of Periodontology, EarlyView.
Abstract Background The relationship between periodontitis and erectile dysfunction (ED) has been poorly documented in Caucasian populations, particularly severe ED (SED) requiring penile prostheses. This study aimed to evaluate the association between periodontitis and SED in patients undergoing penile prosthesis implantation, and to identify clinical
Miguel Ángel Arrabal‐Polo, Ana López‐Toruño, Antonio Magan‐Fernández, Miguel Arrabal Martin, Natividad Martín‐Morales, Eva Rosel, Manuel Bravo, Francisco O´Valle, Francisco Mesa   +8 more
wiley   +1 more source