Results 171 to 180 of about 112,287,737 (220)

C‐ErbB‐2 Oncoprotein Immunostaining In Serous Effusions

Cytopathology, 1993
The product of c‐erbB‐2 gene is detected in a proportion of carcinomas from various sites and is generally associated with a high degree of malignancy. A series of 58 effusions containing malignant cells and 16 cytologically negative serous effusions was assessed by immunocyto‐chemical methods for c‐erbB‐2 expression using the monoclonal antibody NCL ...
ASCOLI, Valeria, C. C.A.R.N.O.V.A.L.E. SCALZO, F. NARDI   +2 more
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C‐erbB‐2 expression and prognostic significance in osteosarcoma

Pediatric Blood & Cancer, 2008
AbstractBackgroundC‐erbB‐2 is postulated as a prognostic biological marker for osteosarcoma (OST). We investigated c‐erbB‐2 expression status in osteosarcomas and its prognostic significance.ProcedureArchival pre‐treatment tumor biopsies of 79 cases were stained by immunohistochemical (IHC) methods with CB11 antibody for cell‐membrane specific c‐erbB‐2
AKYÜZ, CANAN, VARAN, ALİ, YALÇIN, BİLGEHAN, Bueyuekpamukcu, Muenevver, Kutluk, Tezer, Gedikoglu, Goekhan   +5 more
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c-erbB-2 as a target for immunotherapy

Expert Opinion on Investigational Drugs, 1998
The c-erbB-2 proto-oncogene encodes a 185 kDa transmembrane Type 1 tyrosine kinase receptor whose amplification and/or overexpression has been linked with poor prognosis in a variety of cancers. The oncoprotein has been suggested to play a key role in tumour cell invasion, motility and metastasis, and in responsiveness to therapeutic agents.
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Expression of c-erbB-2 in Human Pancreatic Adenocarcinomas

Pathobiology, 2008
The c-erbB-2 (neu) gene encodes a transmembrane phosphoglycoprotein (p185erbB-2) which resembles a growth factor receptor-like molecule closely related to the epidermal growth factor receptor. Overexpression of c-erbB-2 induces cell transformation in vitro.
T M, Williams, D B, Weiner, M I, Greene, H C, Maguire   +3 more
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Amplification of c-erbB-2 Oncogene in Human Adenocarcinomas in Vivo.

Lancet, The, 1986
There are two genes related to the viral erbB gene in the human genome. c-erbB-1 is the same as the gene for the epithelial-growth-factor (EGF) receptor, and c-erbB-2 encodes a receptor-like protein very similar to, but distinct from, the EGF receptor.
Jun Yokota, Masaaki Terada, Kumao Toyoshima   +2 more
exaly   +3 more sources

c-erbB-2 amplification in mammary carcinoma

Journal of Cellular Biochemistry, 1993
The c-erbB-2 oncogene has been extensively studied in mammary carcinomas since Slamon and colleagues demonstrated the association between amplification and poor prognosis in 1987. Further work found that amplification was accompanied by overexpression of the protein; however, this relationship is not perfect.
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c‐erbB‐2 protein is expressed in hepatolithiasis and cholangiocarcinoma

Histopathology, 1998
AimsThe c‐erbB‐2 proto‐oncogene encodes a transmembrane protein which is highly homologous to epidermal growth factor receptor. Overexpression of this c‐erbB‐2 protein has been reported in many human carcinomas, including breast carcinoma. However, there have been few studies of the expression of c‐erbB‐2 in cholangiocarcinoma and hepatolithiasis, a ...
T, Terada, K, Ashida, K, Endo, S, Horie, H, Maeta, Y, Matsunaga, K, Takashima, T, Ohta, Y, Kitamura   +8 more
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Gene Amplification of c- erbB-2 Detected by FISH

2003
In 1981, a novel transforming gene called neu, related to, but distinct from, the c-erbB protooncogene, was identified (1-3). In 1985, two groups independently isolated identical erbB-related genes from human DNA that they called HER-2 (4) and c-erbB-2 (5) located at chromosome band 17q11.2 and encoding a 185,000 Dalton tyrosine kinase (2,4).
S R, Young, W H, Liu, Z R, Wang
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Study on the effects of c-erbB-2-specific antisense oligonucleotides on c-erbB-2 overexpressing breast cancer cells

Journal of Clinical Oncology, 2006
10724 Background: Overexpression of c-erbB2 oncoprotein was always correlated with bad prognostic. In this study, we will research on the effects of c-erbB-2-specific antisense oligonucleotides (ODNs) on c-erbB-2 expression, cell proliferation and apoptosis of c-erbB-2 over-expressing breast cancer TM40D cells, and to further study the effects of c ...
X. Liu, P. Fan, Z. Wu
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c-erbB-2 oncogene expression in hepatocellular carcinoma and cholangiocarcinoma

Journal of Hepatology, 1992
The c-erbB-2 proto-oncogene encodes a transmembrane protein which is homologous to the epidermal growth factor receptor. This protein can be localized immunohistochemically in formalin-fixed paraffin-embedded material using a monoclonal antibody NCL-CB11; positive membrane staining correlates with gene amplification and protein overexpression in breast
JD COLLIER, K GUO, J MATHEW, Felicity May, MK BENNETT, Ian Corbett, Margaret Bassendine, Alastair Burt   +7 more
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