Results 151 to 160 of about 43,518 (188)

The neu (c-erbB-2) oncogene.

Seminars in oncology, 1989
The neu gene was first identified in rat tumors that had been induced by the carcinogen ethyl nitrosourea. The human homolog of neu, usually designated c-erbB-2, is located on chromosome 17, q21. It specifies a transmembrane receptor-like phosphoglycoprotein that is closely related to the EGFr (c-erbB-1). The ligand for c-erbB-2 is not known.
H C, Maguire, M I, Greene
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C-erbB-2 protein in the sera of breast cancer patients

Breast Cancer Research and Treatment, 1992
The c-erbB-2 protein was measured in sera of patients with breast cancer or benign breast diseases to study the significance of this protein as a tumor marker. The mean value and positive rate for this protein (assuming 20U/ml as the cut-off value) were 11.8 U/ml (0%) in benign breast disease (n = 30), 11.8 U/ml (3.1%) in stage I/II primary breast ...
T, Narita, H, Funahashi, Y, Satoh, H, Takagi   +3 more
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Expression of neu/c-erbB-2 in human brain tumors

Human Pathology, 1994
The neu/c-erbB-2 oncogene encodes a 185 kd transmembrane protein (p185). Here we have used the monoclonal antibody (mAb) 3B5 to determine the expression of p185 in a series of fixed biopsy specimens of 180 human brain tumors, including the most frequent entities and, in addition, 18 recurrent gliomas with malignant progression.
K, Schwechheimer, R M, Läufle, W, Schmahl, M, Knödlseder, H, Fischer, H, Höfler   +5 more
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No evidence for c-erbB-2 overexpression in cutaneous melanoma.

Anticancer research, 2001
Recent studies have demonstrated the expression of the c-erbB-2 (HER-2/neu) oncoprotein in several malignant tumors and have related its overexpression with poor prognosis. Because cutaneous melanoma is a malignant tumor associated with poor prognosis, we investigated the expression of c-erbB-2 protein in cutaneous melanoma and in melanoma metastatic ...
Fink-Puches, R, Pilarski, P, Schmidbauer, U, Kerl, H, Soyer, HP   +4 more
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The c-erbB-2 Protein in Primary and Metastatic Breast Carcinomas

Ultrastructural Pathology, 1991
Material from 41 patients with primary breast carcinoma and lymph node metastases at the time of primary surgical intervention was immunostained for c-erbB-2 protein, neuron-specific enolase (NSE), and estrogen receptors. Thirty of the primary breast carcinomas were of ductal type. Six were classified as infiltrating lobular carcinomas, 2 were apocrine,
J M, Nesland, L, Ottestad, A L, Børresen, K E, Tvedt, R, Holm, R, Heikkilä, K, Tveit   +6 more
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Expression of c‐erbB‐2 oncoprotein in human thyroid tumours

Histopathology, 1999
Aimsc‐erbB‐2 expression has been found to be a potential marker of aggressive biological behaviour in some tumours, but the role played by this oncoprotein in the development and maintenance of thyroid tumours is still controversial. Therefore our objective was to determine whether c‐erbB‐2 was overexpressed in a large retrospective series of human ...
J C, Utrilla, I, Martín-Lacave, M V, San Martín, J M, Fernández-Santos, H, Galera-Davidson   +4 more
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Expression of Bcl-2 and c-ErbB-2 in colorectal neoplasia

Pathology & Oncology Research, 2001
Several studies have been demonstrated the value of c-ErbB-2 and Bcl-2 in predicting the biological behaviour of tumors. The aim of this study was to investigate Bcl-2 and c-ErbB-2 expression in colorectal carcinomas and the correlation between their presence and other clinicopathologic parameters.
A, Dursun, A, Poyraz, , Süer O, C, Sezer, G, Akyol   +4 more
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C-erbB-2 expression in primary gastric carcinomas and their metastases

Cancer Genetics and Cytogenetics, 1992
In an attempt to evaluate the relationship between c-erbB-2 expression and/or gene amplification, DNA ploidy and morphology, wall penetration, lymphatic permeation, and vascular invasion, we studied a series of 87 primary gastric carcinomas and their respective metastases (n = 335) using immunohistochemistry and performed DNA analysis of 30 primary ...
L, David, R, Seruca, J M, Nesland, P, Soares, F, Sansonetty, R, Holm, A L, Børresen, M, Sobrinho-Simões   +7 more
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c-erbB-2 Oncogene Expression in Salivary Gland Tumours

ORL, 2010
Prompted by recent findings on the amplification of c-erbB-2 (HER-2, neu) oncogene in salivary gland tumours, the present study was conducted to analyse the expression of c-erbB-2 in both benign and malignant salivary gland tumours, with special emphasis on its prognostic significance and relevance to clinical data.
V, Kärjä, S, Syrjänen, V, Kataja, K, Syrjänen   +3 more
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Quantitative PCR Detection of c- erbB-2 Gene Amplification

2003
The association of c-erbB-2 oncogene amplification and prognostic factors was intensively studied in human gynecological carcinomas, especially in mammary carcinoma (1). Positive lymph nodes, estrogen and progesterone receptor negative tumors, and short survival time correlate with c-erbB-2 amplification.
K, Dobianer, M, Medl, J, Spona
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