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C‐erbB‐2 expression and prognostic significance in osteosarcoma
Pediatric Blood & Cancer, 2008AbstractBackgroundC‐erbB‐2 is postulated as a prognostic biological marker for osteosarcoma (OST). We investigated c‐erbB‐2 expression status in osteosarcomas and its prognostic significance.ProcedureArchival pre‐treatment tumor biopsies of 79 cases were stained by immunohistochemical (IHC) methods with CB11 antibody for cell‐membrane specific c‐erbB‐2
Bilgehan, Yalçin +5 more
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AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO
Lancet, The, 1986There are two genes related to the viral erbB gene in the human genome. c-erbB-1 is the same as the gene for the epithelial-growth-factor (EGF) receptor, and c-erbB-2 encodes a receptor-like protein very similar to, but distinct from, the EGF receptor.
Masaaki Terada +2 more
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c-erbB-2 amplification in mammary carcinoma
Journal of Cellular Biochemistry, 1993The c-erbB-2 oncogene has been extensively studied in mammary carcinomas since Slamon and colleagues demonstrated the association between amplification and poor prognosis in 1987. Further work found that amplification was accompanied by overexpression of the protein; however, this relationship is not perfect.
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c-erbB-2 Gene Amplification in Nasopharyngeal Carcinoma
Cancer Investigation, 2000Amplification of the c-erbB-2 gene has been associated with poor prognosis in different types of cancer. However, there are no data on the c-erbB-2 expression levels in nasopharyngeal cancer. In this study, amplification of the gene has been investigated in the tumor tissue of patients with nasopharyngeal cancer by competitive polymerase chain reaction
H, Yazici +4 more
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c‐erbB‐2 protein is expressed in hepatolithiasis and cholangiocarcinoma
Histopathology, 1998AimsThe c‐erbB‐2 proto‐oncogene encodes a transmembrane protein which is highly homologous to epidermal growth factor receptor. Overexpression of this c‐erbB‐2 protein has been reported in many human carcinomas, including breast carcinoma. However, there have been few studies of the expression of c‐erbB‐2 in cholangiocarcinoma and hepatolithiasis, a ...
T, Terada +8 more
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Gene Amplification of c- erbB-2 Detected by FISH
2003In 1981, a novel transforming gene called neu, related to, but distinct from, the c-erbB protooncogene, was identified (1-3). In 1985, two groups independently isolated identical erbB-related genes from human DNA that they called HER-2 (4) and c-erbB-2 (5) located at chromosome band 17q11.2 and encoding a 185,000 Dalton tyrosine kinase (2,4).
S R, Young, W H, Liu, Z R, Wang
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Journal of Clinical Oncology, 2006
10724 Background: Overexpression of c-erbB2 oncoprotein was always correlated with bad prognostic. In this study, we will research on the effects of c-erbB-2-specific antisense oligonucleotides (ODNs) on c-erbB-2 expression, cell proliferation and apoptosis of c-erbB-2 over-expressing breast cancer TM40D cells, and to further study the effects of c ...
X. Liu, P. Fan, Z. Wu
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10724 Background: Overexpression of c-erbB2 oncoprotein was always correlated with bad prognostic. In this study, we will research on the effects of c-erbB-2-specific antisense oligonucleotides (ODNs) on c-erbB-2 expression, cell proliferation and apoptosis of c-erbB-2 over-expressing breast cancer TM40D cells, and to further study the effects of c ...
X. Liu, P. Fan, Z. Wu
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c- erbB-2 Immunohistochemistry in Paraffin Tumors
2003Immunohistochemistry is the study of the intracellular distribution of antigens based on the formation of an immune complex. The concept is based on the application of a specific antibody to the antigen to be detected and visualization of the antigen-antibody reaction with a staining procedure.
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2003
Overexpression of erbB-2 is important in the pathogenesis of a variety of human neoplasms. Overexpression of the erbB-2 gene product has been associated with poor clinical prognosis with respect to malignancies originating in the ovary, breast, gastrointestinal tract, salivary gland, and lung (1-4) and has led to the development of several therapeutic ...
J, Deshane, R D, Alvarez, G P, Siegal
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Overexpression of erbB-2 is important in the pathogenesis of a variety of human neoplasms. Overexpression of the erbB-2 gene product has been associated with poor clinical prognosis with respect to malignancies originating in the ovary, breast, gastrointestinal tract, salivary gland, and lung (1-4) and has led to the development of several therapeutic ...
J, Deshane, R D, Alvarez, G P, Siegal
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Clinical & Experimental Metastasis, 2002
Overexpression of the c-erbB-2 protein (also called HER-2/neu) is observed in a variety of malignancies including colorectal cancer (CRC). In this study we aimed to evaluate the rate of c-erbB-2 overexpression in our tumor collection and to clarify its correlation with the chromosomal status at the c-erbB-2 locus in CRC.
Thomas, Knösel +7 more
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Overexpression of the c-erbB-2 protein (also called HER-2/neu) is observed in a variety of malignancies including colorectal cancer (CRC). In this study we aimed to evaluate the rate of c-erbB-2 overexpression in our tumor collection and to clarify its correlation with the chromosomal status at the c-erbB-2 locus in CRC.
Thomas, Knösel +7 more
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