Results 211 to 220 of about 2,467,830 (354)

Diversity-Oriented C-H Activation Reactions of the Naphthalene Scaffold. [PDF]

J Am Chem Soc
Fan Z, Hoque ME, Wu K, Palkowitz MD, Velaparthi U, Gillman KW, Qiao JX, Yu JQ.   +7 more
europepmc   +1 more source

One reaction – double stereoinduction: C–H activation as a privileged route towards complex atropisomeric molecules

, 2023
Amandine Luc, Joanna Wencel‐Delord
openalex   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Enantioselective C-H Activation for the Construction of Chiral Tertiary Fluorides via Migrative Carbofluorination. [PDF]

J Am Chem Soc
Zhang ZY, Ouyang Y, Zhang T, Yu JQ.
europepmc   +1 more source

Aerobic C-H bond activation at a Pd center under aqueous conditions.

Dae Young Bae, Nicholas P. Ruhs, Liviu M. Mirica   +2 more
openalex   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Time-Resolved Resonant Inelastic X-ray Scattering Reveals How Orbital Symmetry Alignment Enables C-H Activation. [PDF]

J Am Chem Soc
Dederichs T, Banerjee A, Kabanova V, Stefanuik R, Freibert A, Beale EV, Dworkowski F, Castillo RG, Johnson PJM, Cirelli C, Huse N, Bacellar C, Jay RM, Wernet P.   +13 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Nickel and Copper in C-H Activation and Carbenoid Chemistry: A Descriptor-Based Comparative Analysis of Transition Metals. [PDF]

J Phys Chem A
Gazzari-Jara S, Aroule O, Hoffmann G, Chermette H, Morell C, Herrera B.   +5 more
europepmc   +1 more source

Basicity–Controlled C–H Bond Activation by a Structurally Characterized Ni(III)–Hydroxo Complex [PDF]

Hung‐Ruei Pan, John Wu, Chun-Ming Tsai, Pei-Juan Liao, Hua‐Fen Hsu   +4 more
openalex   +1 more source