Results 241 to 250 of about 3,879,991 (283)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Tandem Cu(I)-Catalyzed Dipolar Cycloaddition-C-H Activation for the In-Flow Synthesis of <i>N</i>-Pyridyl-5-amino-1,2,3-triazole-4-carboxylates. [PDF]

Org Lett
Donato E, Mayorquín-Torres MC, Puglisi A, Benaglia M, Adamo MFA, Stevens CV.   +5 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

CdS Quantum Dot Gels as a Direct Hydrogen Atom Transfer Photocatalyst for C-H Activation. [PDF]

Angew Chem Int Ed Engl
Liu D, Hazra A, Liu X, Maity R, Tan T, Luo L.   +5 more
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Simultaneous construction of inherent and axial chirality by cobalt-catalyzed enantioselective C-H activation of calix[4]arenes. [PDF]

Nat Commun
Li T, Zhang Y, Du C, Yang D, Song MP, Niu JL.   +5 more
europepmc   +1 more source

Structural Reassignment of Covalent Organic Framework-Supported Palladium Species: Heterogenized Palladacycles as Efficient Catalysts for Sustainable C-H Activation. [PDF]

ACS Cent Sci
Sun MY, Cheung SC, Wang XZ, Jin JK, Guo J, Li D, He J.   +6 more
europepmc   +1 more source

Ruthenium(ii) catalyzed C-3 site selective alkenylation of indole derivatives via C-H activation. [PDF]

RSC Adv
Rallabandi J, Mohanty S, Shown I.
europepmc   +1 more source

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Copper Catalyzed C−H Activation

The Chemical Record, 2018
AbstractActivation of C−H bonds and their application in cross coupling chemistry has received a wider interest in recent years. The conventional strategy in cross coupling reaction involves the pre‐functionalization step of coupling reactants such as organic halides, pseudo‐halides and organometallic reagents.
M Lakshmi, Kantam, Chandrakanth, Gadipelly, Gunjan, Deshmukh, K Rajender, Reddy, Suresh, Bhargava   +4 more
openaire   +2 more sources

C–H activation

Current Opinion in Chemical Biology, 1999
Although the biocatalytic activation of carbon-hydrogen bonds by oxidation to alcohols was one of the first biotransformations to be exploited by the chemical industry, this remarkable process continues to be the subject of intense research activity.
openaire   +2 more sources