Results 91 to 100 of about 105,861 (299)

Functionalization of carbon nanotubes with -CHn, -NHn fragments, -COOH and -OH groups

, 2013
We present results of extensive theoretical studies concerning stability, morphology, and band structure of single wall carbon nanotubes (CNTs) covalently functionalized by -CHn(for n=2,3,4),-NHn(for n=1,2,3,4),-COOH and -OH groups. Our studies are based
Majewski, Jacek A., Milowska, Karolina Z.   +1 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Site‐Selective C─H Bond Functionalization of Sugars

Angewandte Chemie International Edition
AbstractNon‐typical C‐functionalized sugars represent a prominent yet hardly accessible class of biologically‐active compounds. The available synthetic methodologies toward such sugar derivatives suffer either from an extensive use of protecting groups, requiring long and laborious synthetic manipulations, or from limited predictability and ...
Stepanova, Elena V., Shatskiy, Andrey, Doroshenko, Ivan, Dinér, Peter, Kärkäs, Markus D.   +4 more
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Designing all-graphene nanojunctions by covalent functionalization

, 2011
We investigated theoretically the effect of covalent edge functionalization, with organic functional groups, on the electronic properties of graphene nanostructures and nano-junctions.
Abe S., Alice Ruini, Barone V., Bekyarova E., Burghard M., Cai J., Caldas M. J., Campos L. C., Cano-Márquez A. G., Castro Neto A. H., Caterina Cocchi, Chen W., Chen Z., Datta S. S., Deborah Prezzi, Dewar M. J. S., Dávila L. Y. A., Elisa Molinari, Farmer D. B., Farmer D. B., Geim A., Han M. Y., Hantal G., Jia X., Jiao L., Kosynkin D. V., Lair S., Li X., Loh K., Lohmann T., Lopez-Bezanilla A., Lu Y. H., Marilia J. Caldas, Nakada K., Novoselov K. S., Ponomarenko L., Prezzi D., Prezzi D., Qian H., Roothaan C. C. J., Sevinçli H., Sinitskii A., Soldano C., Son Y.-W., Sun J. T., Tachikawa H., Venkataraman L., Wang X., Wang X., Wang X., Wetmore S. D., Xia F., Yang L., Yang L., Yang X., Zhang Y.-H.   +55 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Geminal group-directed olefinic C-H functionalization via four- to eight-membered exo-metallocycles

Nature Communications, 2019
Identifying distinct cyclometallation pathways is essential to new types of C-H activation and functionalization in organic synthesis. Here, the authors show the activation of an olefinic C-H bond geminal to the directing group via four- to eight ...
Keke Meng, Tingyan Li, Chunbing Yu, Cong Shen, Jian Zhang, Guofu Zhong   +5 more
doaj   +1 more source

Methodology of the direct C–H bond functionalization in nitrogen-containing heterocycles [PDF]

, 2013
Предложены два эффективных методологических подхода для проведения прямой функционализациии связи С(sp2)–H в альдонитронах. Палладий(II)-катализироуемое окислительное С–С сочетание с индолами и пирролами приводит к нитронам, содержащим N-оксидную функцию.
Varaksin, M. V., Вараксин, М. В.   +1 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Recent advances in C(sp3)–H bond functionalization via metal–carbene insertions

Beilstein Journal of Organic Chemistry, 2016
The recent development of intermolecular C–H insertion in the application of C(sp3)–H bond functionalizations, especially for light alkanes, is reviewed.
Bo Wang, Di Qiu, Yan Zhang, Jianbo Wang
doaj   +1 more source