Results 121 to 130 of about 29,149,024 (329)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
, 2019 The organocatalyzed Mannich reaction of unsubstituted and N-aryl-substituted tetrahydroisoquinolines (THIQs) and the Strecker reaction of several N-aryl-substituted THIQs through dehydrogenative C(sp3)–H bond functionalization (cross-dehydrogenative ...
Bondžić, Bojan, Džambaski, Zdravko
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Functionalization of C-H bond in superacid
, 2021 In recent years, the exploitation of the functionalization of C-H bonds has made great progress. This methodology is becoming one of the main challenges in organic chemistry due to the selectivity and synthetic opportunities it offers, especially for late-stage functionalization.The exploitation of superacidic conditions for the functionalization of C ...
openaire +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ChemElectroChemDirect carboxylation of C(sp3)H bonds with carbon dioxide (CO2) offers an attractive route to value‐added carboxylic acids but remains challenging due to the inertness of both reaction partners.
Yuto Maeji +7 more
doaj +1 more source
Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
Nature Communications, 2018 Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.
Xinxin Wu +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Selective C-H Bond Functionalization of Pyrrolo[1,2-a]quinoxaline
<div style="text-align:justify;"> Pyrrolo[1,2-a]quinoxalines as important heterocyclic compounds have potential application in pharmaceuticals and synthesis due to their wide range of biological activities and pharmacological effects.
Yan Liu, Ping Liu, He Jing
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source