Results 131 to 140 of about 27,070,838 (300)

C–H Functionalization on Carbohydrates

, 2016
Functionalization of C–H bonds has received significant attention in organic chemistry during the last decade and it is still a “hot” topic. In particular, C–H modification of natural products has benefitted from this development.
Pedersen, Christian Marcus, Pedersen, C., Mikael Bols, Christian Marcus Pedersen, Frihed, Tobias Gylling, Frihed, T., Bols, Mikael, Tobias Gylling Frihed, Bols, M.   +8 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Understanding Precatalyst Activation and Speciation in Manganese-Catalyzed C-H Bond Functionalization Reactions. [PDF]

Organometallics, 2023
Eastwood JB, Hammarback LA, Burden TJ, Clark IP, Towrie M, Robinson A, Fairlamb IJS, Lynam JM.   +7 more
europepmc   +1 more source

sp3 C–H Bond Functionalization with Ruthenium Catalysts

, 2014
International audienceThe selective formation of carbon–carbon bond by functionalization of an sp3C–H bond is still a challenge in organic synthesis. There are already examples involving transition metal catalysis.
Christian Bruneau, Bruneau, Christian
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Selective C-H Bond Functionalization of Pyrrolo[1,2-a]quinoxaline

<div style="text-align:justify;"> Pyrrolo[1,2-a]quinoxalines as important heterocyclic compounds have potential application in pharmaceuticals and synthesis due to their wide range of biological activities and pharmacological effects.
Yan Liu, Ping Liu, He Jing
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

C–H Trifluoromethylthiolation of aldehyde hydrazones

Beilstein Journal of Organic Chemistry
The selective C–H trifluoromethylthiolation of aldehyde hydrazones afforded interesting fluorinated building blocks, which could be used as a synthetic platform.
Victor Levet, Balu Ramesh, Congyang Wang, Tatiana Besset   +3 more
doaj   +1 more source

Co(II)-Catalyzed Picolinamide-Directed C(sp³)-S Bond Formation with N-(phenylsulfanyl)succinimides

Molecules
Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp3)-H bond formation with N-(phenylsulfanyl)succinimides.
Jinjing Qin, Shaodong Zhou, Jinwen Luo, Guodong Wang, Kai Wang   +4 more
doaj   +1 more source

Aromatic C-H bond functionalization through organocatalyzed asymmetric intermolecular aza-Friedel-Crafts reaction: a recent update. [PDF]

Beilstein J Org Chem, 2023
Biswas A.
europepmc   +1 more source