Results 151 to 160 of about 27,070,838 (300)

C–H functionalization via single atom metathesis of C–H and C–X bonds

Journal of the American Chemical Society
Metathesis and reversible catalytic reactions are fundamentally intriguing and powerful tools in modern synthetic chemistry. While most reversible catalytic reactions are predicated on breaking and forming reactive functional groups, the ability to leverage the C–H bond as a functional group into metathesis reactions has proved to be exceptionally ...
Tanner Jankins, Barnabé Berger, Françoise Aouane, Sergio Barbeira-Arán, Christophe Didier, Bettina Hürlimann, Claudius Zimmer, Bill Morandi   +7 more
openaire   +3 more sources

DFT Studies of Ru-Catalyzed C–O versus C–H Bond Functionalization of Aryl Ethers with Organoboronates

, 2017
Density functional theory calculations have been performed to investigate how different nucleophiles and directing groups affect the preference of C-H versus C-O bond functionalization in the ruthenium-catalyzed coupling reactions of aryl ethers with ...
Zheng Wang, Zhenyang Lin, Wai Han Lam, Zhou, Yu, Wang, Zheng, Lam, Wai Han, Yu Zhou, Lin, Zhenyang   +7 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Rieske Oxygenase Catalyzed C-H Bond Functionalization Reactions in Chlorophyll b Biosynthesis. [PDF]

ACS Cent Sci, 2022
Liu J, Knapp M, Jo M, Dill Z, Bridwell-Rabb J.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Ruthenium-catalysed decarboxylative unsymmetric dual ortho-/meta-C-H bond functionalization of arenecarboxylic acids. [PDF]

Chem Sci, 2023
Li X, Wang X, Zhang J.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Room‐Temperature Direct Homolysis of Csp3─H Bond via Catalyst‐Free Photoexcitation

Exploration
The C─H bond is the most abundant chemical bond in organic compounds. Therefore, the development of the more direct methods for C─H bond cleavage and the elucidation of their mechanisms will provide an important theoretical basis for achieving more ...
Qi Miao, Meng Liu, Jun Wang, Pan Wu, Changjun Liu, Jian He, Giacomo Lo Zupone, Wei Jiang   +7 more
doaj   +1 more source

Biocatalytic, Intermolecular C-H Bond Functionalization for the Synthesis of Enantioenriched Amides. [PDF]

Angew Chem Int Ed Engl, 2021
Athavale SV, Gao S, Liu Z, Mallojjala SC, Hirschi JS, Arnold FH.   +5 more
europepmc   +1 more source