Results 251 to 260 of about 29,149,024 (329)

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Ruthenium-catalyzed C5-H activation of indole-4-carboxylic acids with alkynes: access to pyrano-indolone scaffolds. [PDF]

RSC Adv
Mohanty SR, Bande O, Mohanty SK, Dhanajirane D, Thatai JT.   +4 more
europepmc   +1 more source

Aluminum Cation-Catalyzed C2-H Activation and Enantioselective Michael Addition of Indoles. [PDF]

J Org Chem
Hsu CP, Wen CC, Liu CA, Hong LH, Liao WC, Liu YH, Chen WC, Chiu CW.   +7 more
europepmc   +1 more source

Development of Organocatalytic Functionalizations of C-H Bonds

, 2017
openaire   +1 more source

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Organocatalysis in Inert C–H Bond Functionalization

Chemical Reviews, 2017
As two coexisting and fast-growing research fields in modern synthetic chemistry, the merging of organocatalysis and C-H bond functionalization is well foreseeable, and the joint force along this line has been demonstrated to be a powerful approach in making inert C-H bond functionalization more viable, predictable, and selective.
Lihui Zhu, Sanzhong Luo
exaly   +4 more sources

Rhodium-Catalyzed C-H Bond Functionalization with Amides by Double C-H/C-N Bond Activation.

Organic Letters, 2016
The first C-H bond functionalization with amides as the coupling partners via selective activation of the amide N-C bond using rhodium(I) catalysts under highly chemoselective conditions is reported. Notably, this report constitutes the first catalytic activation of the amide N-C(O) bond by rhodium.
Guangrong Meng, M. Szostak
semanticscholar   +4 more sources

C?H Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

Angewandte Chemie - International Edition, 2012
Kenichiro Itami, Junichiro Yamaguchi, Atsushi D Yamaguchi   +2 more
exaly   +2 more sources