Results 11 to 20 of about 18,976,803 (305)
PLoS ONE, 2012 BACKGROUND: A given tumor is usually dependent on the oncogene that is activated in the respective tumor entity. This phenomenon called oncogene addiction provides the rationale for attempts to target oncogene products in a therapeutic manner, be it by ...
Frank M Lehmann +9 more
doaj +6 more sources
Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc
International Journal of Hyperthermia, 2022 Background Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. Objective We hypothesized that
Xiaole Li +9 more
doaj +2 more sources
Translocations involving c-myc and c-myc function [PDF]
Oncogene, 2001 c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed.
Chi Dang, Linda M Boxer, L M Boxer
exaly +3 more sources
Nanobody‐Mediated c‐MYC Degradation Inhibits Tumor Cell Progression [PDF]
MedCommThe c‐MYC oncogene, a critical driver of malignancies, is frequently associated with poor prognosis because it promotes unchecked cell proliferation and alters gene expression.
Yuanyuan Xue +7 more
doaj +2 more sources
Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis [PDF]
Journal of Experimental & Clinical Cancer Research, 2018 Background The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequences determined the discrepancy ...
Matteo Caforio +5 more
doaj +2 more sources
ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC [PDF]
Frontiers in OncologyZinc Finger Protein 161 (ZFP161) is a key regulator of Ataxia Telangiectasia and Rad3-related (ATR) signaling, playing a crucial role in maintaining genomic stability.
Grania Christyani +7 more
doaj +2 more sources
Identification and validation of the role of c-Myc in head and neck squamous cell carcinoma
Frontiers in Oncology, 2022 BackgroundMany studies have shown that c-Myc plays a critical role in tumorigenesis. However, the molecular role of c-Myc in head and neck squamous cell carcinoma (HNSC) remains unclear.MethodsSeveral biological databases, including UALCAN, TIMER2.0 ...
Sufeng Zhao +5 more
doaj +1 more source
Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8
Cancer Biology & Therapy, 2022 Overexpression of c-myc via increased transcription or decreased protein degradation is common to many cancer etiologies. c-myc protein degradation is mediated by ubiquitin-dependent degradation, and this ubiquitylation is regulated by several E3 ligases.
Sagar Bajpai +3 more
doaj +1 more source
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit
Acta Pharmaceutica Sinica B, 2022 The dysregulation of transcription factors is widely associated with tumorigenesis. As the most well-defined transcription factor in multiple types of cancer, c-Myc can transform cells by transactivating various downstream genes.
Xiaomeng Gao +10 more
doaj +1 more source
Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc
Scientific Reports, 2023 c-Myc, a transcription factor, induces cell proliferation and is often aberrantly or highly expressed in cancers. However, molecular mechanisms underlying this aberrantly high expression remain unclear.
Takahiro Masaki +6 more
doaj +1 more source