Results 11 to 20 of about 20,867,404 (313)
PLoS ONE, 2012 BACKGROUND: A given tumor is usually dependent on the oncogene that is activated in the respective tumor entity. This phenomenon called oncogene addiction provides the rationale for attempts to target oncogene products in a therapeutic manner, be it by ...
Frank M Lehmann +9 more
doaj +5 more sources
Stem Cell Research & Therapy, 2019 Background Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of ...
Svitlana Melnik +6 more
doaj +2 more sources
Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma
Cancer Cell, 2017 SUMMARY Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e.g. T cell lymphoma (TCL).
Yang Xu, Byung-Wook Kim
exaly +2 more sources
Nanobody‐Mediated c‐MYC Degradation Inhibits Tumor Cell Progression [PDF]
MedCommThe c‐MYC oncogene, a critical driver of malignancies, is frequently associated with poor prognosis because it promotes unchecked cell proliferation and alters gene expression.
Yuanyuan Xue +7 more
doaj +2 more sources
ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC [PDF]
Frontiers in OncologyZinc Finger Protein 161 (ZFP161) is a key regulator of Ataxia Telangiectasia and Rad3-related (ATR) signaling, playing a crucial role in maintaining genomic stability.
Grania Christyani +7 more
doaj +2 more sources
Identification and validation of the role of c-Myc in head and neck squamous cell carcinoma
Frontiers in Oncology, 2022 BackgroundMany studies have shown that c-Myc plays a critical role in tumorigenesis. However, the molecular role of c-Myc in head and neck squamous cell carcinoma (HNSC) remains unclear.MethodsSeveral biological databases, including UALCAN, TIMER2.0 ...
Sufeng Zhao +5 more
doaj +1 more source
c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment
Cell Communication and Signaling, 2023 The MYC oncogenic family is dysregulated in diverse tumors which is generally linked to the poor prognosis of tumors. The members in MYC family are transcription factors which are responsible for the regulation of various genes expression.
Fangyan Gao +4 more
semanticscholar +1 more source
Ubiquitylation of unphosphorylated c-myc by novel E3 ligase SCFFbxl8
Cancer Biology & Therapy, 2022 Overexpression of c-myc via increased transcription or decreased protein degradation is common to many cancer etiologies. c-myc protein degradation is mediated by ubiquitin-dependent degradation, and this ubiquitylation is regulated by several E3 ligases.
Sagar Bajpai +3 more
doaj +1 more source
Translocations involving c-myc and c-myc function [PDF]
Oncogene, 2001 c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed.
L M, Boxer, C V, Dang
openaire +2 more sources
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit
Acta Pharmaceutica Sinica B, 2022 The dysregulation of transcription factors is widely associated with tumorigenesis. As the most well-defined transcription factor in multiple types of cancer, c-Myc can transform cells by transactivating various downstream genes.
Xiaomeng Gao +10 more
doaj +1 more source