Results 11 to 20 of about 19,205,329 (382)
PLoS ONE, 2012 BACKGROUND: A given tumor is usually dependent on the oncogene that is activated in the respective tumor entity. This phenomenon called oncogene addiction provides the rationale for attempts to target oncogene products in a therapeutic manner, be it by ...
Frank M Lehmann +9 more
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Translocations involving c-myc and c-myc function [PDF]
Oncogene, 2001 c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed.
L M, Boxer, C V, Dang
openaire +2 more sources
Target c-Myc to treat pancreatic cancer
Cancer Biology & Therapy, 2022 C-Myc overexpression is a common finding in pancreatic cancer and predicts the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby regulating their transcription.
Moein Ala
semanticscholar +1 more source
Oncogene, 2021 The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of breast cancer tumors. However, the underlying mechanism is not fully understood.
Pengpeng Zhu +12 more
semanticscholar +1 more source
Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc
Scientific Reports, 2023 c-Myc, a transcription factor, induces cell proliferation and is often aberrantly or highly expressed in cancers. However, molecular mechanisms underlying this aberrantly high expression remain unclear.
Takahiro Masaki +6 more
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Cell Communication and Signaling, 2022 Background Transcription factor c-Myc plays a critical role in various physiological and pathological events. c-Myc gene rearrangement is closely associated with multiple myeloma (MM) progression and drug resistance.
Ruosi Yao +6 more
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Rabring7 degrades c-Myc through complex formation with MM-1. [PDF]
PLoS ONE, 2012 We have reported that a novel c-Myc-binding protein, MM-1, repressed E-box-dependent transcription and transforming activities of c-Myc and that a mutation of A157R in MM-1, which is often observed in patients with leukemia or lymphoma, abrogated all of ...
Rina Narita +6 more
doaj +1 more source
Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc
International Journal of Hyperthermia, 2022 Background Hyperthermia is a widely used adjunct treatment for different cancers including nasopharyngeal carcinoma (NPC). The protooncogene c-Myc is up-regulated in NPC and its expression is associated with poor prognosis. Objective We hypothesized that
Xiaole Li +9 more
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Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc
Molecular Cancer, 2020 c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, suggesting this
S. Madden +4 more
semanticscholar +1 more source
c-Myc accelerates S-phase and requires WRN to avoid replication stress. [PDF]
PLoS ONE, 2009 c-Myc interacts with components of the pre-replication complex and directly regulates DNA replication [1]. However the consequences of this novel c-Myc function on cell cycle dynamics and replication-associated damage are unknown.
Kristin Robinson +3 more
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