Results 251 to 260 of about 14,797,528 (308)

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Triglyceride lipase PNPLA2-independent suppression of c-MYC signaling by the metabolic coactivator ABHD5 in prostate cancer. [PDF]

J Biol Chem
Lotvola A, Chen G, Zhou G, Granneman JG, Wang J.   +4 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

c-Myc Inhibits Macrophage Antimycobacterial Response in Mycobacterium tuberculosis Infection. [PDF]

J Infect Dis
Sarti E, Dollé C, Wolfensberger R, Kusejko K, Russenberger D, Bredl S, Speck RF, Greter M, Rueschoff JH, Boeck L, Mai D, Jahn AN, Gold ES, Liu D, Diercks AH, Sander P, Olson GS, Nemeth J.   +17 more
europepmc   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

NIBAN2 Stimulates Glioma Growth by Regulating the JAK2/STAT3/c-Myc Pathway. [PDF]

Cancer Med
Chen ZM, Mou L, Pan YH, Feng C, Liu J, Zhang JJ, Yan CX.   +6 more
europepmc   +1 more source

c-Myc transactivates CFL1 to induce senescence-like phenotype and potentiate the bystander effects for the migration and proliferation in lung cancer cells. [PDF]

Cell Death Discov
Chou YT, Leu JD, Yang WY, Li CH, Lin MY, Kao CW, Chang YC, Hsiao M, Lee YJ.   +8 more
europepmc   +1 more source

KAT3B acts as an oncogene in PCa by mediating the succinylation of c-Myc and promoting its stability. [PDF]

World J Surg Oncol
Nie W, Cha S, Fu Q.
europepmc   +1 more source

Letter regarding HOXA9 drives lymphatic metastasis by activating the c-MYC-glycolysis-lactate axis in gastric cancer. [PDF]

J Transl Med
Zhang X, Wang Z, Xie J, Zhang F.
europepmc   +1 more source