Results 261 to 270 of about 14,797,528 (308)

Epithelial AhR Suppresses Allergen-Induced Oxidative Stress and Senescence via c-Myc Regulation. [PDF]

Antioxidants (Basel)
Chen Z, Gu W, Wan R, Zeng Y, Xiang X, Ouyang R, Gao P.   +6 more
europepmc   +1 more source

Analysis of <i>Fusobacterium nucleatum</i> Driven Modulation of c-Myc Pathways in Oral Carcinogenesis. [PDF]

F1000Res
Priya C, Jain A, Shetty DC, Pai Khot AJ, Yadav S, Jain M, Gulati N, Almalki SA, Gowdar IM.   +8 more
europepmc   +1 more source

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c-Myc-driven Hepatocarcinogenesis

Anticancer Research, 2021
Dysregulation of the c-Myc gene is frequently found in human hepatocellular carcinoma (HCC), often accompanied by genetic and epigenetic alterations in other cancer-related genes. Here, we investigated the tumorigenic potential of c-Myc in diverse genetic environments in which the Ras, Wnt/β-catenin, Sonic hedgehog, or P53 pathways were either ...
Hyuk, Moon, Hyunjung, Park, Simon Weonsang, Ro   +2 more
openaire   +2 more sources

Association with C-Myc: An Alternated Mechanism for c-Myc Function

1995
The c-myc proto-oncogene encodes a ubiquitously expressed nuclear phospho-protein that is involved in the control of cellular proliferation and differentiation (1, 2, 3). Alteration of the c-myc locus by chromosomal translocation, amplification or retroviral insertion is often associated with tumorigenesis in different species including humans (1, 3 ...
A, Shrivastava, K, Calame
openaire   +2 more sources

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

The International Journal of Biochemistry & Cell Biology, 2011
The c-Myc oncoprotein plays critical roles in multiple biological processes by controlling cell proliferation, apoptosis, differentiation, and metabolism. Especially, c-Myc is frequently overexpressed in many human cancers and widely involved in tumorigenesis.
Beibei, Mao, Guowei, Zhao, Xiang, Lv, Hou-Zao, Chen, Zheng, Xue, Ben, Yang, De-Pei, Liu, Chih-Chuan, Liang   +7 more
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Function of the c‐Myc oncoprotein

The FASEB Journal, 1992
The c‐Myc protein, the product of the c‐myc proto‐oncogene, is a nuclear phosphoprotein with DNA binding properties. Deregulated c‐myc expression participates in the development of experimentally induced tumors, and its expression appears to be abnormal
G J, Kato, C V, Dang
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The many faces of c-MYC

Archives of Biochemistry and Biophysics, 2003
The proto-oncogene c-MYC is implicated in various physiological processes-cell growth, proliferation, loss of differentiation, and cell death (apoptosis). Oncogenic c-MYC implies constitutive or deregulated expression of c-MYC and is associated with many human cancers often with poor prognosis.
Stella, Pelengaris, Mike, Khan
openaire   +2 more sources

A transcriptional repressor of c-myc

Nature, 1989
In murine plasmacytomas there is deregulated transcription of a translocated c-myc allele and undetectable transcription of the normal, unrearranged c-myc allele. Deregulated c-myc transcription probably contributes to the transformed phenotype of the tumour cells, whereas repression of the normal allele probably reflects the normal turn-off of c-myc ...
E, Kakkis, K J, Riggs, W, Gillespie, K, Calame   +3 more
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Activation of the c-myc Oncogene

1986
Activated forms of the c-myc oncogene have been linked to cell transformation in a variety of mammalian and avian tumors. Several mechanisms of gene activation have been described, but each mechanism gives rise to constitutive levels of expression, usually no higher than that found in proliferating normal cells.
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Expression of c-myc and Pvt1

1990
Deregulated expression of c-myc secondary to chromosomal alterations is a constant feature of mouse plasmacytomas, rat immunocytomas and human Burkitt lymphomas (Mushinski, 1988). One feature of deregulated expression of c-myc is that all plasmacytomas have high levels of c-myc transcripts, no matter whether their chromosome 15 was interrupted by a ...
J F, Mushinski, R M, Skurla, J, Goodnight, D, Siwarski, K, Huppi   +4 more
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