Results 271 to 280 of about 19,205,329 (382)

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

Regulatory role of transcription factor c-Myc in the pathogenesis of psoriasis. [PDF]

PeerJ
Cao Y, Niu XP, Zhang KM.
europepmc   +1 more source

UNR/ <i>CSDE1</i> Expression Is Critical to Maintain Invasive Phenotype of Colorectal Cancer Through Regulation of c-MYC and Epithelial-to-Mesenchymal Transition

, 2019
Javier Martínez‐Useros, Nuria Garcia-Carbonero, Weiyao Li, María Jesús Fernández‐Aceñero, Ion Cristóbal, Raúl Rincón, Maria Rodriguez-Reminez, Aurea Borrero‐Palacios, Jesús García‐Foncillas   +8 more
openalex   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Targeting c-Myc enhances immunotherapy efficacy in combination with Ras inhibitor in triple-negative breast cancer. [PDF]

Clin Transl Med
Liang X, Liu Y, Zhu Y, Zhao Y, Ye F, Gao F, Shi Y, Guan X.   +7 more
europepmc   +1 more source

Nuclear BIN1 isoforms regulate c-Myc-mediated cell cycle control in oligodendrocytes [PDF]

Iris Wai‐Ting, Sunny Hoi‐Sang Yeung, Gerald Wai‐Yeung Cheng, Martin Ho-Yin Yeung, Julia Kofler, Karl Herrup, Kai‐Hei Tse   +6 more
openalex   +1 more source

IFN-γ regulates the transformation of microglia into dendritic-like cells via the ERK/c-myc signaling pathway during cerebral ischemia/reperfusion in mice

, 2020
Haiyu Zhang, Tongshuai Zhang, Dandan Wang, Yixiang Jiang, Tieyun Guo, Yao Zhang, Fan Zhu, Kaiyu Han, Lili Mu, Guangyou Wang   +9 more
openalex   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

CMSP suppresses oral squamous cell carcinoma progression by targeting the JAK2/STAT3/c-Myc axis. [PDF]

Front Oncol
Lu Y, Yao M, Wang D, Higuchi D, Lu H, Shang H, Dong B, Zhang J, Jin R, Liu T.   +9 more
europepmc   +1 more source

c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer

Clinical Cancer Research, 2016
A. Nebbioso, V. Carafa, Mariarosaria Conte, F. P. Tambaro, C. Abbondanza, J. Martens, M. Nees, R. Benedetti, I. Pallavicini, S. Minucci, G. Garcia-Manero, F. Iovino, G. Lania, Concetta Ingenito, V. Belsito Petrizzi, H. Stunnenberg, L. Altucci   +16 more
semanticscholar   +1 more source