Results 51 to 60 of about 19,205,329 (382)
c-Myc and Cancer Metabolism [PDF]
Clinical Cancer Research, 2012 Abstract The processes of cellular growth regulation and cellular metabolism are closely interrelated. The c-Myc oncogene is a “master regulator” which controls many aspects of both of these processes. The metabolic changes which occur in transformed cells, many of which are driven by c-Myc overexpression, are necessary to support the ...
Donald M, Miller +4 more
openaire +2 more sources
Mutations and amplification of oncogenes in endometrial cancer [PDF]
, 1999 Alterations in oncogenes are critical steps in the development of endometrial cancer. To investigate the potential clinical relevance of the amplification of the oncogenes c-erbB2, c-myc, and int-2 and the mutation of K-ras in endometrial cancer, 112 ...
An, Han-Xiang +5 more
core +1 more source
The IRE1 ER stress sensor activates natural killer cell immunity in part by regulating c-Myc
Nature Immunology, 2019 Natural killer (NK) cells are critical mediators of host immunity to pathogens. Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1 ...
Han Dong +8 more
semanticscholar +1 more source
Association of Helicobacter pylori with colorectal cancer development. [PDF]
, 2010 Background: Helicobacter pylori (H. pylori) may be associated with colorectal cancer. However, the underlying mechanisms are still unclear. Objectives: Explore the serostatus of H.
Abdulamir, Ahmed Sahib +4 more
core +1 more source
c-Myc Regulates Transcriptional Pause Release [PDF]
Cell, 2010 Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA-binding transcription factors is well recognized as a key regulatory step in gene expression. We report here that promoter-proximal pausing is a general feature of transcription by Pol II in mammalian cells and thus an additional step where ...
P. Rahl +7 more
semanticscholar +5 more sources
FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity [PDF]
Journal of Biological Chemistry, 2015 FBXO32 (MAFbx/Atrogin-1) is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. Although some data indicate that FBXO32 may play an important role in tumorigenesis, the molecular mechanism of FBXO32 in tumorigenesis has been poorly understood.
Zhichao, Mei +5 more
openaire +2 more sources
c-Myc regulates cell proliferation during lens development. [PDF]
PLoS ONE, 2014 Myc protooncogenes play important roles in the regulation of cell proliferation, growth, differentiation and survival during development. In various developing organs, c-myc has been shown to control the expression of cell cycle regulators and its ...
Gabriel R Cavalheiro +4 more
doaj +1 more source
A Positive Role of c-Myc in Regulating Androgen Receptor and its Splice Variants in Prostate Cancer
Oncogene, 2019 Increased expression of the full-length androgen receptor (AR-FL) and AR splice variants (AR-Vs) drives the progression of castration-resistant prostate cancer (CRPC).
S. Bai +15 more
semanticscholar +1 more source
Direct activation of RNA polymerase III transcription by c-Myc
, 2003 The proto-oncogene product c-Myc has a direct role in both metazoan cell growth and division. RNA polymerase III (pol III) is involved in the generation of transfer RNA and 5S ribosomal RNA, and these molecules must be produced in bulk to meet the need ...
Eisenman, R.N. +3 more
core +1 more source
Elevated myc expression and c-myc amplification in spontaneously occurring B lymphoid cell lines [PDF]
, 1987 Recently, a minor subpopulation of murine B lymphocytes, Ly-1+ B cells, has been distinguished by its unique ontogeny, tissue distribution, and prominence in certain autoimmune and neoplastic B cell diseases.
Baltimore, David +2 more
core +1 more source