Results 61 to 70 of about 19,205,329 (382)

SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62 [PDF]

Oncogene, 2015
Serine 62 (Ser62) phosphorylation affects the c-Myc protein stability in cancer cells. However, the mechanism for dephosphorylating c-Myc is not well understood. In this study, we identified carboxyl-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (SCP1) as a novel phosphatase specifically dephosphorylating c-Myc Ser62.
W, Wang, P, Liao, M, Shen, T, Chen, Y, Chen, Y, Li, X, Lin, X, Ge, P, Wang   +8 more
openaire   +2 more sources

Therapeutic Potential of the Cyclin-Dependent Kinase Inhibitor Flavopiridol on c-Myc Overexpressing Esophageal Cancer

Frontiers in Pharmacology, 2021
Tumors with elevated c-Myc expression often exhibit a highly aggressive phenotype, and c-Myc amplification has been shown to be frequent in esophageal cancer.
Md Sazzad Hassan, Md Sazzad Hassan, Nicholas Cwidak, Chloe Johnson, Silvio Däster, Serenella Eppenberger-Castori, Niranjan Awasthi, Niranjan Awasthi, Jun Li, Jun Li, Margaret A. Schwarz, Margaret A. Schwarz, Urs von Holzen, Urs von Holzen, Urs von Holzen, Urs von Holzen   +15 more
doaj   +1 more source

The mTORC2‐Akt1 Cascade Is Crucial for c‐Myc to Promote Hepatocarcinogenesis in Mice and Humans

Hepatology, 2019
Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment options. The c‐Myc transcription factor is a pivotal player in hepatocarcinogenesis, but the mechanisms underlying c‐Myc oncogenic activity in the liver remain poorly ...
Zhong Xu, Meng Xu, Pin Liu, Shu Zhang, R. Shang, Y. Qiao, L. Che, S. Ribback, A. Cigliano, K. Evert, R. Pascale, F. Dombrowski, M. Evert, Xi Chen, D. Calvisi, Xin Chen   +15 more
semanticscholar   +1 more source

c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells [PDF]

, 2007
Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases.
Anthony P. H. Wright, Chiou-Nan Shiue, Rachel G. Berkson   +2 more
core   +1 more source

mRNA in exosomas as a liquid biopsy in non-Hodgkin Lymphoma: a multicentric study by the Spanish Lymphoma Oncology Group [PDF]

, 2017
Purpose: To determine the feasibility of mRNAs (C-MYC, BCL-XL, BCL-6, NF-κβ, PTEN and AKT) in exosomes of plasma as a liquid biopsy method for monitoring and prognostic evolution in B-cell lymphomas.
Cantos, Blanca, García, Vanesa, García-Arroyo, Francisco R., GOTEL (Spanish Lymphoma Oncology Group), Maximiano, Constanza, Provencio, Mariano, Quero, Cristina, Rodríguez, Marta, Rodríguez-Abreu, Delvys, Rueda, Antonio, Sabín, Pilar, Silva, Javier, Sánchez, Antonio   +12 more
core   +4 more sources

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity [PDF]

Proceedings of the National Academy of Sciences, 2012
The oncogenic transcription factor c-Myc causes transformation and tumorigenesis, but it can also induce apoptotic cell death. Although tumor suppressors are necessary for c-Myc to induce apoptosis, the pathways and mechanisms are unclear.
Qin, Zhang, Erick, Spears, David N, Boone, Zhaoliang, Li, Mark A, Gregory, Stephen R, Hann   +5 more
openaire   +2 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Antitumor Effect of Anti‐c‐Myc Aptamer‐Based PROTAC for Degradation of the c‐Myc Protein

Advanced Science
Targeting “undruggable” targets with intrinsically disordered structures is of great significance for the treatment of disease. The transcription factor c‐Myc controls global gene expression and is an attractive therapeutic target for multiple types of ...
Yuchun Wang, Gang Yang, Xinyu Zhang, Ruoling Bai, Deyu Yuan, Denghui Gao, Qianyu He, Yi Yuan, Xinghe Zhang, Junchuang Kou, Lihua Zheng, Yanxin Huang, Zhuo Tang, Yongli Bao, Xu Song, Yongyun Zhao   +15 more
doaj   +1 more source

siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells

Journal of Experimental & Clinical Cancer Research, 2008
The c-Myc and human telomerase reverse transcriptase gene (hTERT) gene are frequently deregulated and overexpressed in malignancy. hTERT activity is induced by c-Myc and strategies designed to inhibit c-Myc expression in cancer cells may have ...
Guofu Huang, Wen Su, Xiong Wei, Lei Fu, Nancai Yu, Hao Huang, yanxia Wu, Hanju Huang, Qian Liu, Hong Xiao   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source