Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia? [PDF]
Biomedicines, 2020 Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2–5 min). It is theorised that c-
Lynda Guildford +2 more
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Utility of the random C-peptide and random C-peptide index at diagnosis as a predictor of disease type and long-term insulin secretory capacity in children with diabetes mellitus [PDF]
Endocrine JournalThe random C-peptide and random C-peptide index (CPI) have been shown to be useful in assessing endogenous insulin secretory capacity in adults with type 2 diabetes. This study aimed to clarify the utility of C-peptide and the CPI in early classification
Keita Numasawa +8 more
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An Antibody Cocktail-Based Immunoaffinity-LC-MS Method Enabled Ultra-Sensitive and Robust Quantification of Circulating Proinsulin Proteoforms and C-Peptide. [PDF]
Anal ChemShen Q +12 more
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Comparison of proinsulin to C-peptide ratio in children with and without type 1 diabetes and its relation to age [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2020 Purpose This study aimed to compare the proinsulin to C-peptide (PI:C) ratio in those with recent-onset type 1 diabetes versus those with no diabetes and to explore the effect of age on PI:C ratio.
Benjamin R. Ellison +2 more
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Fasting serum C-peptide level may not be low in young-onset diabetes
Journal of Diabetology, 2022 Background: Diabetes mellitus (DM) is one of the growing health problems among the young population. Secretory defect of insulin is an important cause, and it can be assessed by measuring fasting serum C-peptide level.
Mobarak Hosen +9 more
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Association of High Sensitivity C-Reactive Protein with the Components of Metabolic Syndrome in Diabetic and Non-Diabetic Individuals [PDF]
Journal of Clinical and Diagnostic Research, 2014 Background and Objectives: High sensitivity C-reactive protein (hsCRP) has been associated with metabolic syndrome (MetS) and its components. Several studies have suggested hsCRP to be used as a marker for the primary prevention of cardiovascular ...
Manoj Sigdel +5 more
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Diabetes type 2 in young people. Clinical case from the practice of endocrinologist
Клинический разбор в общей медицине, 2021 In recent decades, type 2 diabetes is increasingly recorded in young people, adolescents and children. The most significant risk factors for type 2 diabetes in young patients are family history of the disease, overweight and obesity, and the presence of ...
Galina A. Batrak, Maria V. Zhaburina
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Journal of Diabetes Research, 2003 For years an assumption was made that C‐peptide, a byproduct of insulin biosynthesis, possessed no appreciable physiologic role. As other contributions in this volume amply testify, the time has come to re‐evaluate that notion. C‐peptide either directly through interaction with its specific cell‐surface receptor or indirectly through an interaction ...
Grunberger, George, Sima, Anders A. F.
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Asian Journal of Medical Sciences, 2022 Background: Surgery is a stress which stimulates the increase of counter regulatory hormones. Pre-operative prolonged fasting increases stress further.
Arif Hossain +4 more
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Glutamic Acid Decarboxylase and Islet Cell Cytoplasmic Autoantibodies Positivity in Latent Autoimmune Diabetes of Adults: Need for Early Insulinisation [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Latent Autoimmune Diabetes of Adults (LADA) remains a poorly understood disease at both the clinical and research level and usually misdiagnosed as Type 2 Diabetes Mellitus (T2DM) and treated with Oral Hypoglycaemic Agents (OHA).
KS Priyadarshini +2 more
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