Results 261 to 270 of about 1,300,723 (292)

Correlations Between Fasting Plasma C-Peptide, Glucagon-Stimulated Plasma C-Peptide, and Urinary C-Peptide in Insulin-Treated Diabetics

Diabetes Care, 1987
This study correlated fasting plasma C-peptide (CP), plasma CP 6 min after stimulation with 1 mg glucagon i.v., and the mean of three 24-h urinary excretions of C-peptide (UCP)/creatinine in 132 insulin-treated diabetics. Patients were divided into three groups: group 1, stimulated CP < 0.06 nM (n = 51); group 2, stimulated CP 0.067−0.60 nM (n =
Gjessing, H J, Matzen, L E, Frøland, A, Faber, O K   +3 more
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Heterogeneity of Circulating C-Peptide

The Journal of Clinical Endocrinology & Metabolism, 1977
Serum C-peptide levels vary when measured with different immunoassay systems. In order to assess the factors contributing to this finding, serum C-peptide was measured in two assays utilizing different antisera, but the same standards and labeled peptide.
H, Kuzuya, P M, Blix, D L, Horwitz, A H, Rubenstein, D F, Steiner, C, Binder, O K, Faber   +6 more
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Proinsulin C-Peptide-Biological Activity?

Science, 1997
Patients with diabetes can lead relatively normal lives when treated with the hormone insulin, although they eventually exhibit vascular and neural complications. Now a report in this week9s issue by Ido et al. (p. 563) suggests that these complications might be alleviated by the simultaneous administration of C-peptide, a protein fragment cleaved ...
D F, Steiner, A H, Rubenstein
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C‐PEPTIDE IN JUVENILE DIABETES

Acta Paediatrica, 1977
Abstract. C‐peptide can be used as a measure of endogenous insulin secretion in insulin treated diabetics with insulin antibodies. At the onset of juvenile diabetes insulin production is thought to be absent or minimal, but we have found rather high levels of C‐peptide, even in ketoacidotic patients. The ketoacidosis does not mean an irreversible beta
J, Ludvigsson, L G, Heding
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Erroneous C-Peptide Values Given?

Archives of Internal Medicine, 1982
To the Editor. —A letter regarding permanent remission of ketotic diabetes with subsequent normal C-peptide secretion was published in theArchives(1981;141:960-961) by Harstine and co-workers. Their data for C-peptide in their table and their contention that the patient had subsequent normal values for this polypeptide are probably erroneous if the ...
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C-peptide and diabetic neuropathy

Expert Opinion on Investigational Drugs, 2003
Diabetic polyneuropathy (DPN) is the most common chronic complication of diabetes and affects Type 1 diabetic patients disproportionately. In the last two decades it has become increasingly evident that underlying metabolic, molecular and functional mechanisms and, ultimately, structural changes differ in DPN between the two major types of diabetes. In
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Persistent C-peptide

Current Opinion in Endocrinology, Diabetes & Obesity, 2013
The assumption that patients with an extended duration of type 1 diabetes mellitus (T1D) do not retain residual functional β cells and endogenous insulin production has recently been challenged. The purpose to this review is to highlight some of the key emerging evidence supporting residual insulin and C-peptide secretion in long-standing T1D.Recent ...
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Clinical Significance of C-Peptide

1979
Significant information has accumulated in recent years regarding the biochemical and morphological details of insulin biosynthesis and secretion. Insulin is formed in pancreatic beta-cells through enzymatic splitting of a precursor molecule, proinsulin, which itself is a product of the proteolysis of an even larger molecule, preproinsulin (Chan, Keim,
A H, Rubenstein, B, Gonen
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C-Peptide

Pancreas, 2004
During the past decade, numerous studies in both humans and animals have demonstrated that C-peptide, although not influencing blood sugar control, might play a role in preventing and potentially reversing some of the chronic complications of type 1 diabetes. The aim of this paper is to present an up-to-date review of C-peptide, focusing on its role in
Ruy G, Marques, Magali J, Fontaine, Jeffrey, Rogers   +2 more
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Characterization of Seven C-peptide Antisera

Diabetes, 1978
The plasma C-peptide immunoreactivity (CPR) in 10 normal subjects varied considerably when measured with different antisera in parallel assays. The CPR level correlated with the blank “CPR” value measured in plasma devoid of C-peptide and to a lesser degree with the sensitivity of the standard curves obtained with the individual antisera.
O K, Faber, C, Binder, J, Markussen, L G, Heding, V K, Naithani, H, Kuzuya, P, Blix, D L, Horwitz, A H, Rubenstein   +8 more
openaire   +2 more sources