Results 81 to 90 of about 1,300,723 (292)

The Application of the Insulin to C-Peptide Molar Ratio (ICPR) in Primary Screening for Insulin Antibodies in Type 2 Diabetes Mellitus Patients: A Further Quantitative Study on the Relationship Between ICPR and Insulin Antibodies

Diabetes, Metabolic Syndrome and Obesity, 2023
Kai-Fang Hua,1,2 Bo-Yang Jing,3 Yan-Hui Wu1,4 1Department of Endocrinology, Xiang’an Hospital of Xiamen University, Xiamen, Fujian, People’s Republic of China; 2School of Medicine, Xiamen University, Xiamen, Fujian, People’s Republic of China; 3Hai Yuan ...
Hua KF, Jing BY, Wu YH
doaj  

A Prospective 1-Year Follow-up of Glycemic Status and C-Peptide Levels of COVID-19 Survivors with Dysglycemia in Acute COVID-19 Infection [PDF]

Diabetes & Metabolism Journal
Background We evaluated changes in glycemic status, over 1 year, of coronavirus disease 2019 (COVID-19) survivors with dysglycemia in acute COVID-19. Methods COVID-19 survivors who had dysglycemia (defined by glycosylated hemoglobin [HbA1c] 5.7% to 6.4 ...
David Tak Wai Lui, Chi Ho Lee, Ying Wong, Carol Ho Yi Fong, Kimberly Hang Tsoi, Yu Cho Woo, Kathryn Choon Beng Tan   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Gliclazide challenge testing as an alternative diagnostic tool for hepatocyte nuclear factor-1-alpha maturity onset diabetes of the young

European Journal of Case Reports in Internal Medicine
Background: Hepatocyte nuclear factor-1-alpha monogenic diabetes (HNF1-alpha DM), formerly known as maturity-onset diabetes of the young type 3 (MODY 3), is often misdiagnosed as type 1 or type 2 diabetes. In regions where genetic testing is unavailable,
Sunjay Pandya, Rutbah Khairati, Jesheen Mann, Lucy Archer, Ponnusamy Saravanan, Fernando Erneta III, Vinod Patel   +6 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Lowest Glucagon/Highest C-Peptide in Oral Glucose Tolerance Test: Clinical Utility in Monitoring Glucose Control in Type 2 Diabetes Mellitus

Diabetes, Metabolic Syndrome and Obesity
Lina Chang,* Xiaohui Ma,* Menghua Yuan,* Li Ding, Yian Gu, Lili Liu, Yan Li, Hua Shu, Ming Liu, Qing He Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China*These ...
Chang L, Ma X, Yuan M, Ding L, Gu Y, Liu L, Li Y, Shu H, Liu M, He Q   +9 more
doaj  

Natriuretic peptide C receptor in the developing sheep lung: role in perinatal transition [PDF]

, 2017
Bobby Mathew, Christopher A. D’Angelis, Satyan Lakshminrusimha, Peter A. Nickerson, June Sokolowski, Vasanth Kumar, Huamei Wang, Karen Wynn, Bruce A. Holm, Rita M. Ryan   +9 more
openalex   +1 more source

Supplementary Movie S2 from Aggressive Progression in Glioblastoma Cells through Potentiated Activation of Integrin α5β1 by the Tenascin-C–Derived Peptide TNIIIA2

, 2023
Motomichi Fujita, Tetsuya Yamamoto, Takuya Iyoda, Tatsuya Fujisawa, Manabu Sasada, Reo Nagai, Chikako Kudo, Kazuki Otsuka, Sadahiro Kamiya, Hiroaki Kodama, Fumio Fukai   +10 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source